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Titolo:
The role of medial prefrontal cortical dopamine in spontaneous flexibilityin the rat
Autore:
Lanser, MG; Ellenbroek, BA; Zitman, FG; Heeren, DJ; Cools, AR;
Indirizzi:
Univ Med Ctr St Radboud, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands NL-6500 HB gen, Netherlands Univ Med Ctr St Radboud, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands NL-6500 HB gen, Netherlands
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 163 - 171
SICI:
0955-8810(200106)12:3<163:TROMPC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL WORKING-MEMORY; LOCOMOTOR STEREOTYPY; NUCLEUS-ACCUMBENS; LATENT INHIBITION; FRONTAL-CORTEX; SCHIZOPHRENIA; BEHAVIOR; AMPHETAMINE; D-1; RECEPTORS;
Keywords:
spontaneous flexibility; prefrontal cortex; dopamine; D-1 receptor; D-2 receptor; open field; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ellenbroek, BA Univ Med Ctr St Radboud, Dept Psychoneuropharmacol, POB 9101, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud POB 9101 Nijmegen Netherlands NL-6500 HB
Citazione:
M.G. Lanser et al., "The role of medial prefrontal cortical dopamine in spontaneous flexibilityin the rat", BEHAV PHARM, 12(3), 2001, pp. 163-171

Abstract

In rat studies, both lesions in the medial prefrontal cortex (mPFC) and alterations of the level of mPFC dopamine (DA) have been found to induce disturbances in behavioural flexibility, as measured with switching tasks. It is not clear whether mPFC DA is also involved in spontaneous flexibility, Therefore, the aim of the present study was to investigate the role of mPFC DA in spontaneous flexibility. As a measure for spontaneous flexibility, thediversity in spatial distribution of exploration on a large open field wasused. The rats received local injections into the mPFC with a D-1 or D-2 antagonist, or the dopamimetic, amphetamine, The results showed that both DAantagonists reduced spontaneous flexibility, due to increased stimulus-bound behaviour. Amphetamine had a similar effect to the DA antagonists. It issuggested that this is most likely due to an amphetamine-induced increase in extracellular DA, leading to a suboptimal level of mPFC DA, (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:35:03