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Titolo:
An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice
Autore:
Belzung, C; Le Guisquet, AM; Barreau, S; Calatayud, F;
Indirizzi:
UFR Sci & Tech, Psychobiol Emot EA 3248, F-37200 Tours, France UFR Sci & Tech Tours France F-37200 Emot EA 3248, F-37200 Tours, France
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 151 - 162
SICI:
0955-8810(200106)12:3<151:AIOTMR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A RECEPTOR ANTAGONIST; FREELY-MOVING RATS; EXTRACELLULAR DOPAMINE; ANXIETY DISORDERS; PREFRONTAL CORTEX; ANIMAL-MODELS; DIALYSATE LEVELS; SEROTONIN-UPTAKE; PANIC DISORDER; PLUS-MAZE;
Keywords:
5-HT1A receptor ligands; 5-HT2 receptors ligands; anxiety; BALB/c mice; CCKB receptor antagonist; CRF1 receptor antagonist; dopamine receptor antagonists; fluoxetine; free exploration test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Belzung, C UFR Sci & Tech, Psychobiol Emot EA 3248, Parc Grandmont, F-37200 Tours, France UFR Sci & Tech Parc Grandmont Tours France F-37200 urs, France
Citazione:
C. Belzung et al., "An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice", BEHAV PHARM, 12(3), 2001, pp. 151-162

Abstract

Although selective 5-hydroxytryptamine (5-HT) reuptake inhibitors (SSRIs) are widely used in the chronic treatment of several anxiety disorders, increased anxiety has been observed in some patients at the beginning of treatment with these compounds. Similar increases in anxiety-related behaviors have been observed in animal studies following a single injection with SSRIs. The mechanism underlying this effect is unclear. The aim of the present study was to investigate the effects of a variety of psychoactive compounds on the anxiogenic-like activity of fluoxetine. The drugs used included the benzodiazepine diazepam, the 5-HT1A receptor partial agonist buspirone, the 5-HT1A receptor antagonists pindolol and WAY-100635, the non-selective 5-HT2 receptor antagonists methiothepin, mianserin and ritanserin, the non-selective dopamine (DA) receptor antagonist haloperidol, the D-1 antagonist SCH23390, the selective D-2 antagonist raclopride, the D-2/3 agonist quinelorane, the cholecystokinin(B) (CCKB) receptor antagonist LY 288513, and the corticotropin-releasing factor(1) (CRF1) receptor antagonist CP-154,526. Experiments were performed in the free-exploration test. This model is based onthe strong neophobic reactions exhibited by BALB/c mice when confronted simultaneously with a familiar and a novel environment. When administered alone, diazepam (1 and 2 mg/kg), buspirone (1 mg/kg) and mianserin (0.3 mg/ kg) produced anxiolytic-like effects as they significantly increased exploratory activity of the novel compartment. In contrast, fluoxetine (20mg/kg) almost completely suppressed exploration of the novel area. Diazepam reversedthe anxiogenic-like as well as the locomotor impairment induced by fluoxetine, while quinelorane blocked only the anxiogenic action of fluoxetine. None of the other compounds was able to counteract this effect, Taken together, these results suggest that dopaminergic mechanisms may underlie, at least in part, the behavioral effects of fluoxetine in the free-exploration test, whereas 5-HT1A, 5-HT2, CCKB and CRF1 receptors may not be involved primarily in these effects, (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:39:50