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Titolo:
LYMPHOMATOID PAPULOSIS TYPE-A - CLINICAL, MORPHOLOGIC, AND IMMUNOPHENOTYPIC STUDY
Autore:
SIOUTOS N; ASVESTI C; SIVRIDIS E; AYGERINOU G; TSEGA A; ZAKOPOULOU N; ZOGRAPHAKIS I;
Indirizzi:
18 SAKI KARAGIORGA ATHENS 16675 GREECE A SYGROS HOSP,DEPT DERMATOL ATHENS GREECE GEORGETOWN UNIV,DEPT PATHOL WASHINGTON DC 00000 DEMOCRITUS UNIV THRACE,DEPT PATHOL ALEXANDROUPOLIS GREECE
Titolo Testata:
International journal of dermatology
fascicolo: 7, volume: 36, anno: 1997,
pagine: 514 - 517
SICI:
0011-9059(1997)36:7<514:LPT-CM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMA; HODGKINS-DISEASE; SPECTRUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
N. Sioutos et al., "LYMPHOMATOID PAPULOSIS TYPE-A - CLINICAL, MORPHOLOGIC, AND IMMUNOPHENOTYPIC STUDY", International journal of dermatology, 36(7), 1997, pp. 514-517

Abstract

Background Lymphomatoid papulosis (LyP) is a cutaneous clonal or polyclonal Ki-1 + T-cell lymphoproliferative disorder, morphologically resembling Ki-1 + anaplastic large cell lymphomas (Ki-1 + ALCL) or Hodgkin's disease (HD). Lymphomatoid papulosis usually has a characteristic benign clinical course with remissions and relapses of the cutaneous eruptions. Methods The authors studied three patients with LyP. In eachcase the diagnosis was established based on the typical clinical history and presentation of the cutaneous lesions as well as the morphologic and immunophenotypic findings. Results In all three cases the skin biopsies showed a polymorphic, nonepidermotropic, dermal lymphocytic infiltrate, composed of small lymphocytes and fewer large, atypical cells. The large cells were positive for the activation markers CD30 (Ki-1) and CD45R (leukocyte common antigen), and were negative for the HD marker CD15 (Leu MI). Conclusions In most cases, LyP can be distinguished from Ki-1 + ALCL and HD on the basis of clinical, morphologic, and/or immunophenotypic findings, We emphasize the importance of the recognition of LyP as a clinicopathologic entity and the awareness of dermatologists, oncologists, and surgical pathologists in differentiating LyP from other primary cutaneous Ki-1 + lymphoproliferative disorders (Ki-1 + ALCL and HD). The prognosis of cutaneous Ki-1 + ALCL and HD isusually different from LyP and requires a different therapeutic approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 21:49:38