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Titolo:
Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones - The MORGEN Study
Autore:
Tabak, C; Arts, ICW; Smit, HA; Heederik, D; Kromhout, D;
Indirizzi:
Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands Natl Inst Publ Hlth & Environm, Div Publ Hlth Res, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands Univ Utrecht, Div Environm & Occupat Hlth, Inst Risk Assessment Sci, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands k Assessment Sci, Utrecht, Netherlands Univ Wageningen & Res Ctr, State Inst Qual Control Agr Prod, Wageningen, Netherlands Univ Wageningen & Res Ctr Wageningen Netherlands ageningen, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 164, anno: 2001,
pagine: 61 - 64
SICI:
1073-449X(200107)164:1<61:COPDAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIALLY ANTICARCINOGENIC FLAVONOIDS; EPIDEMIOLOGIC EVIDENCE; FRUIT JUICES; NETHERLANDS; TEA; DETERMINANTS; VEGETABLES; DECLINE; ADULTS; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Smit, HA Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, POB 1, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm POB 1 Bilthoven Netherlands NL-3720 BA
Citazione:
C. Tabak et al., "Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones - The MORGEN Study", AM J R CRIT, 164(1), 2001, pp. 61-64

Abstract

Flavonoids have been suggested to protect against chronic lung disease. Westudied intake of catechins, flavonols, and flavones in relation to pulmonary function and COPD symptoms in 13,651 adults from three Dutch cities examined from 1994 to 1997. Dietary intake was estimated using a food frequency questionnaire, and flavonoid intake was calculated using specific food composition tables. Pulmonary function (FEV1) was determined by spirometry and COPD symptoms by questionnaire. Associations were presented for the fifthversus the first quintile of intake (Q5-Q1), adjusted for age, height (forFEV1 only), sex, smoking, BMI, and energy intake. Smoking was strongly associated with COPD, independent of dietary effects. Average catechin, flavonol, and flavone intake was 58 mg/d (SD = 46) with tea and apples as main sources. Total catechin, flavonol, and flavone intake was positively associated with FEV1 (beta (Q5-Q1) = 44 ml, 95% CI = 18-69) and inversely associated with chronic cough (ORQ5-Q1 = 0.80, 95% CI = 0.66-0.97) and breathlessness (ORQ5-Q1 = 0.74, 95% CI = 0.58-0.94), but not chronic phlegm. Catechin intake was independently associated with FEV1 (beta (Q5-Q1) = 130 ml, 95% CI = 101-159) and all three COPD symptoms (ORQ5-Q1 = 0.60-0.72, p < 0.001). Flavonol and flavone intake was independently associated with chronic cough only. Solid fruit, but not tea, intake was beneficially associated with COPD. Our results suggest a beneficial effect of a high intake of catechins andsolid fruits against COPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:12:47