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Titolo:
Structural brain abnormalities in chronic schizophrenia at the extremes ofthe outcome spectrum
Autore:
Staal, WG; Pol, HEH; Schnack, HG; van Haren, NEM; Seifert, N; Kahn, RS;
Indirizzi:
Univ Utrecht Hosp, Dept Psychiat, NL-3584 CX Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3584 CX CX Utrecht, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 158, anno: 2001,
pagine: 1140 - 1142
SICI:
0002-953X(200107)158:7<1140:SBAICS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCALE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Staal, WG Univ Utrecht Hosp, Dept Psychiat, Heidelberglaan 100, NL-3584 CXUtrecht, Netherlands Univ Utrecht Hosp Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
W.G. Staal et al., "Structural brain abnormalities in chronic schizophrenia at the extremes ofthe outcome spectrum", AM J PSYCHI, 158(7), 2001, pp. 1140-1142

Abstract

Objective: This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia. Method: Intracranial volume and volumes of the cerebrum, gray and white matter, lateral and third ventricles, frontal lobes, thalamus, and cerebellumwere measured in 20 patients with a poor outcome, 25 with a favorable outcome, and 23 healthy comparison subjects with magnetic resonance imaging. Results: Thalamic volume was significantly smaller both in poor-outcome patients and good-outcome patients. In contrast, only poor-outcome patients displayed significantly smaller cerebral gray matter, particularly prefrontal, and enlargement of the lateral and third ventricles. No significant differences were found for intracranial, cerebellar, or cortical CSF volumes. Conclusions: Smaller thalamic volumes in schizophrenia may reflect a greater susceptibility for the disorder and seem unrelated to outcome. In contrast, gray matter volume loss of the cerebrum, particularly in the frontal lobes, and lateral and third ventricular enlargement appear related to outcome in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:53:23