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Titolo:
Functional neuroanatomy of visuospatial working memory in fragile X syndrome: Relation to behavioral and molecular measures
Autore:
Kwon, H; Menon, V; Eliez, S; Warsofsky, IS; White, CD; Dyer-Friedman, J; Taylor, AK; Glover, GH; Reiss, AL;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Radiol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Neurosci Program, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 rosci Program, Stanford, CA 94305 USA Stanford Univ, Sch Med, Stanford Brain Res Ctr, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Brain Res Ctr, Stanford, CA 94305 USA Kimball Genet Inc, Denver, CO USA Kimball Genet Inc Denver CO USAKimball Genet Inc, Denver, CO USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 158, anno: 2001,
pagine: 1040 - 1051
SICI:
0002-953X(200107)158:7<1040:FNOVWM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENTAL-RETARDATION PROTEIN; HUMAN PREFRONTAL CORTEX; FEMALE CARRIERS; FRONTAL LOBES; ACTIVATION; TASKS; MRI; MALES; FMRI; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kwon, H Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, 401 Quarry Rd, Stanford, CA 94305 USA Stanford Univ 401 Quarry Rd Stanford CA USA 94305 rd, CA 94305 USA
Citazione:
H. Kwon et al., "Functional neuroanatomy of visuospatial working memory in fragile X syndrome: Relation to behavioral and molecular measures", AM J PSYCHI, 158(7), 2001, pp. 1040-1051

Abstract

Objective: Fragile X syndrome is a neurogenetic disorder that is the most common known heritable cause of neurodevelopmental disability. This study examined the neural substrates of working memory in female subjects with fragile X syndrome. Possible correlations among behavioral measures, brain activation, and the FMR1 gene product (FMRP expression), as well as between IQand behavioral measures, were investigated. Method: Functional magnetic resonance imaging was used to examine visuospatial working memory in 10 female subjects with fragile X syndrome and 15 typically developing female subjects (ages 10-23 years). Subjects performed standard 1-back and 2-back visuospatial working memory tasks. Brain activation was examined in four regions of the cortex known to play a critical rolein visuospatial working memory Correlations between behavioral, neuroimaging, and molecular measures were examined. Results: Relative to the comparison group, subjects with fragile X syndrome performed significantly worse on the 2-back task but not on the 1-back task. In a region-of-interest analysis focused on the inferior frontal gyrus,middle frontal gyrus, superior parietal lobule, and supramarginal gyrus, comparison subjects showed significantly increased brain activation between the 1-back and 2-back tasks, but subjects with fragile X syndrome showed nochange in activation between the two tasks. Significant correlations were found in comparison subjects between activation in the frontal and parietalregions and the rate of correct responses on the 2-back task, but not on the 1-back task. In subjects with fragile X syndrome, significant correlations were found during the 2-back task between FMRP expression and activationin the right inferior and bilateral middle frontal gyri and the bilateral supramarginal gyri. Conclusions: Subjects with fragile X syndrome are unable to modulate activation in the prefrontal and parietal cortex in response to an increasing working memory load, and these deficits are related to a lower level of FMRP expression in fragile X syndrome subjects than in normal comparison subjects. The observed correlations between biological markers and brain activation provide new evidence for links between gene expression and cognition.

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Documento generato il 05/04/20 alle ore 04:04:37