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Titolo:
Central blockade of vasopressin V-1 receptors attenuates postexercise hypotension
Autore:
Collins, HL; Rodenbaugh, DW; DiCarlo, SE;
Indirizzi:
Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA Wayne StateUniv Detroit MI USA 48201 Dept Physiol, Detroit, MI 48201 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: R375 - R380
SICI:
0363-6119(200108)281:2<R375:CBOVVR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; BAROREFLEX FUNCTION; DYNAMIC EXERCISE; BLOOD-PRESSURE; AREA POSTREMA; ARGININE-VASOPRESSIN; HYPERTENSIVE MEN; VOLUME EXPANSION; CONSCIOUS RATS; DORSAL HORN;
Keywords:
arginine vasopressin; arterial baroreflex resetting; cardiopulmonary baroreflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: DiCarlo, SE Wayne State Univ, Sch Med, Dept Physiol, 540 E Canfield Ave, Detroit, MI 48201 USA Wayne State Univ 540 E Canfield Ave Detroit MI USA 48201 1 USA
Citazione:
H.L. Collins et al., "Central blockade of vasopressin V-1 receptors attenuates postexercise hypotension", AM J P-REG, 281(2), 2001, pp. R375-R380

Abstract

We tested the hypothesis that central arginine vasopressin (AVP) mediates postexercise reductions in arterial pressure (AP) and heart rate (HR). To test this hypothesis, nine spontaneously hypertensive rats (SHR) were instrumented with a 22-gauge stainless steel guide cannula in the right lateral cerebral ventricle and with a carotid arterial catheter. After the rats recovered, AP and HR were assessed before and after a single bout of dynamic exercise with the central administration of vehicle or the selective AVP V-1-receptor antagonist d(CH3)(5) Tyr(Me)-AVP (AVP-X). AP and HR were significantly decreased below preexercise values with central administration of vehicle [P< 0.05, change (<Delta>) -21 +/- 4 mmHg and Delta -20 +/- 6 beats/min, respectively]. In sharp contrast, after exercise with central administration of AVP-X, both AP (Delta +8 +/- 5 mmHg) and HR (Delta +24 +/- 9 beats/min) were not significantly different from preexercise values (P> 0.05). Furthermore, AVP-X at rest did not significantly alter AP (181 +/- 11 vs. 178 /- 11 mmHg, P> 0.05) or HR (328 +/- 24 vs. 331 +/- 22 beats/min, P> 0.05). Thus central blockade of AVP V-1 receptors prevented postexercise reductions in AP and HR. These data suggest that AVP, acting within the central nervous system, mediates postexercise reductions in AP and HR in the SHR.

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Documento generato il 13/07/20 alle ore 08:02:43