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Titolo:
Health-related quality of life in chronic liver disease: The impact of type and severity of disease
Autore:
Younossi, ZM; Boparai, N; Price, LL; Kiwi, ML; McCormick, M; Guyatt, G;
Indirizzi:
Inova Fairfax Hosp, Dept Med, Ctr Liver Dis, Falls Church, VA 22042 USA Inova Fairfax Hosp Falls Church VA USA 22042 , Falls Church, VA 22042 USA Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, OH 44195 USA McMaster Univ, Hamilton, ON, Canada McMaster Univ Hamilton ON CanadaMcMaster Univ, Hamilton, ON, Canada
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 7, volume: 96, anno: 2001,
pagine: 2199 - 2205
SICI:
0002-9270(200107)96:7<2199:HQOLIC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; OF-LIFE; OUTCOMES; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Younossi, ZM Inova Fairfax Hosp, Dept Med, Ctr Liver Dis, 330 Gallows Rd, Falls Church,VA 22042 USA Inova Fairfax Hosp 330 Gallows Rd Falls Church VAUSA 22042 A
Citazione:
Z.M. Younossi et al., "Health-related quality of life in chronic liver disease: The impact of type and severity of disease", AM J GASTRO, 96(7), 2001, pp. 2199-2205

Abstract

OBJECTIVE: The type and severity of chronic liver disease may have different effects on health-related quality of life (HRQL). The aim of our study was to determine whether HRQL in patients with chronic liver disease differsby type and severity of disease and to identify which clinical and physiological factors affect this impairment. METHODS: In this study, HRQL was measured with a generic (Short Form 36) and a liver disease-specific (Chronic Liver Disease Questionnaire) questionnaire. Clinical, demographic, and laboratory data were collected at office visits. Patient's HRQL scores were compared with the published norms and to the chronically ill populations. A total of 353 patients (mean age 50 yr, 51% men) with chronic liver disease, either viral disease (hepatitis B and C), cholestatic disease (primary biliary cirrhosis or primary sclerosing cholangitis), or hepatocellular disease were enrolled in the study. RESULTS: In general, HRQL in patients with chronic liver disease was lowerthan the normal population and was similar to that of patients with chronic obstructive pulmonary disease or congestive heart failure. In cirrhotic patients, some dimensions of HRQL were less impaired in patients with cholestatic disease than in those with hepatocellular diseases. More severe disease (higher Child's class) was associated with a lower Chronic Liver DiseaseQuestionnaire score and the Short Form 36's physical component summary scores. Older age had a weak negative association with the physical aspects ofHRQL. CONCLUSIONS: We conclude that chronic liver disease substantially reduces HRQL, and this impact does not differ markedly by type of disease. Older age and measures of disease severity were associated with poorer HRQL. (C) 2001 by Am. Cell. of Gastroenterology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:04:43