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Titolo:
Effects on 24-hour intragastric pH: A comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously
Autore:
Freston, J; Chiu, YL; Pan, WJ; Lukasik, N; Taubel, J;
Indirizzi:
Univ Connecticut, Ctr Hlth, Farmington, CT 06032 USA Univ Connecticut Farmington CT USA 06032 r Hlth, Farmington, CT 06032 USA Abbott Labs, Abbott Pk, IL 60064 USA Abbott Labs Abbott Pk IL USA 60064Abbott Labs, Abbott Pk, IL 60064 USA TAP Pharmaceut Prod, Lake Forest, IL USA TAP Pharmaceut Prod Lake Forest IL USA rmaceut Prod, Lake Forest, IL USA Stamford Hosp, Charterhouse Clin Res Unit, London, England Stamford Hosp London England harterhouse Clin Res Unit, London, England
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 7, volume: 96, anno: 2001,
pagine: 2058 - 2065
SICI:
0002-9270(200107)96:7<2058:EO2IPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; GASTROESOPHAGEAL REFLUX DISEASE; CAPSULE DOSAGE FORMULATION; OMEPRAZOLE; PHARMACODYNAMICS; SUPPRESSION; VOLUNTEERS; INHIBITION; ULCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Freston, J Univ Connecticut, Ctr Hlth, 263 Farmington Ave,Bldg 20, Farmington, CT 06032 USA Univ Connecticut 263 Farmington Ave,Bldg 20 Farmington CTUSA 06032
Citazione:
J. Freston et al., "Effects on 24-hour intragastric pH: A comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously", AM J GASTRO, 96(7), 2001, pp. 2058-2065

Abstract

OBJECTIVE: To compare the 24-h intragastric pH effects of lansoprazole, 30mg administered nasogastrically, with pantoprazole, 40 mg administered i.v. METHODS: Healthy adults were enrolled in an open label, two-way crossover,single-center study. Thirty milligrams of lansoprazole (administered nasogastrically in apple juice) or pantoprazole (i.v.) were administered once daily at 8:00 AM for 5 consecutive days with at least a 2-wk washout period between the, regimens. Ambulatory 24-h intragastric pH was monitored at baseline and on days 1 and 5 of each treatment period. Blood specimens were collected on days 1 and 5 for pharmacokinetic parameter determinations. RESULTS: Thirty-three adults completed both crossover periods, with the exception of one patient with a zero lansoprazole plasma concentration on day1 of period 2. Lansoprazole, 30 mg per nasogastric tube, produced significantly higher mean 24-h intragastric pH values relative to pantoprazole, 40 mg Lv., on both day 1 (3.05 vs 2.76, p < 0.002) and day 5 (3.65 vs 3.45, p = 0.024). Lansoprazole sustained the intragastric pH above 3 (days 1 and 5), 4, and 5 (day 1) significantly longer relative to pantoprazole. Lansoprazole's time to the maximum observed concentration and area under the plasma concentration-time curve over the 24-h time interval increased significantly from day 1 to day 5 (1.7 h vs 2.0 h and 1865 ng<bullet>h/ml vs 2091 ng .h/ml, respectively), and a significant increase in half-life relative to day1 (0.96 h) was observed on day 5 (1.03 h) during pantoprazole treatment. CONCLUSION: Lansoprazole, 30 mg administered nasogastrically, effectively controls intragastric pH and is an alternative to i.v. pantoprazole in patients who are unable to swallow solid dosage formulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:12:55