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Titolo:
Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa
Autore:
Fideli, OS; Allen, SA; Musonda, R; Trask, S; Hahn, BH; Weiss, H; Mulenga, J; Kasolo, F; Vermund, SH; Aldrovandi, GM;
Indirizzi:
Univ Alabama, Sch Med, Dept Pediat, Birmingham, AL 35294 USA Univ AlabamaBirmingham AL USA 35294 ept Pediat, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Microbiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Microbiol, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Med, Div Geog Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 v Geog Med, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Med, Div Hematol & Oncol, Birmingham, AL 35294USA Univ Alabama Birmingham AL USA 35294 tol & Oncol, Birmingham, AL 35294USA Trop Dis Res Ctr, Ndola, Zambia Trop Dis Res Ctr Ndola ZambiaTrop Dis Res Ctr, Ndola, Zambia Zambia Natl Blood Transfus Serv, Lusaka, Zambia Zambia Natl Blood TransfusServ Lusaka Zambia sfus Serv, Lusaka, Zambia Univ Teaching Hosp, Virol & Immunol Lab, Lusaka, Zambia Univ Teaching Hosp Lusaka Zambia p, Virol & Immunol Lab, Lusaka, Zambia
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 10, volume: 17, anno: 2001,
pagine: 901 - 910
SICI:
0889-2229(200107)17:10<901:VAIDOH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
WOMAN SEXUAL TRANSMISSION; FEMALE GENITAL-TRACT; CD4 TEST KIT; VIRAL LOAD; RISK-FACTORS; RNA LEVELS; PERINATAL TRANSMISSION; ANTIRETROVIRAL THERAPY; ZIDOVUDINE TREATMENT; DISCORDANT COUPLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Aldrovandi, GM Univ Alabama, Sch Med, Dept Pediat, 845 19th St S,BBRB 559,Birmingham, AL35294 USA Univ Alabama 845 19th St S,BBRB 559 Birmingham AL USA 35294
Citazione:
O.S. Fideli et al., "Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa", AIDS RES H, 17(10), 2001, pp. 901-910

Abstract

More than 80% of the world's HIV-infected adults live in sub-Saharan Africa, where heterosexual transmission is the predominant mode of spread. The virologic and immunologic correlates of female-to-male (FTM) and male-to-female (MTF) transmission are not well understood. A total of 1022 heterosexual couples with discordant HIV-1 serology results (one partner HIV infected,the other HIV uninfected) were enrolled in a prospective study in Lusaka, Zambia and monitored at 3-month intervals. A nested case-control design wasused to compare 109 transmitters and 208 nontransmitting controls with respect to plasma HIV-1 RNA (viral load, VL), virus isolation, and CD4(+) celllevels. Median plasma VL was significantly higher in transmitters than nontransmitters (123,507 vs. 51,310 copies/ml, p < 0.001). In stratified multivariate Cox regression analyses, the risk ratio (RR) for FTM transmission was 7.6 (95% CI: 2.3, 25.5) for VL <greater than or equal to> 100,000 copies/ml and 4.1 (95% CI: 1.2, 14.1) for VL between 10,000 and 100,000 copies/mlcompared with the reference group of,10,000 copies/ml. Corresponding RRs for MTF transmission were 2.1 and 1.2, respectively, with 95% CI both bounding 1. Only 3 of 41 (7%) female transmitters had VL, 10, 000 copies/ml compared with 32 of 93 (34%) of female nontransmitters (p, 0.001). The transmission rate within couples was 7.7/100 person-years and did not differ from FTM (61/862 person-years) and MTF (81/978 person-years) transmission. We conclude that the association between increasing plasma viral load was strong for female to male transmission, but was only weakly predictive of male to female transmission in Zambian heterosexual couples. FTM and MTF transmission rates were similar. These data suggest gender-specific differences in thebiology of heterosexual transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:09:51