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Titolo:
At acidic pH, the GPA2-cAMP pathway is necessary to counteract the ORDI-mediated repression of the hypoxic SRPI/TIRI yeast gene
Autore:
Bourdineaud, JP;
Indirizzi:
Univ Bordeaux 2, Fac Oenol, F-33405 Talence, France Univ Bordeaux 2 Talence France F-33405 ac Oenol, F-33405 Talence, France
Titolo Testata:
YEAST
fascicolo: 9, volume: 18, anno: 2001,
pagine: 841 - 848
SICI:
0749-503X(20010630)18:9<841:AAPTGP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; STRESS-RESPONSE; PROTEIN; EXPRESSION; ENCODES; RAS; TRANSCRIPTION; SENSITIVITY; CISPLATIN; GLUCOSE;
Keywords:
stress response; hypoxia; SRP1; TIR1; HOG pathway; GPA2-cAMP pathway; pH regulation; PKA pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bourdineaud, JP Univ Bordeaux 2, Fac Oenol, 351 Cours Liberat, F-33405 Talence, France Univ Bordeaux 2 351 Cours Liberat Talence France F-33405
Citazione:
J.P. Bourdineaud, "At acidic pH, the GPA2-cAMP pathway is necessary to counteract the ORDI-mediated repression of the hypoxic SRPI/TIRI yeast gene", YEAST, 18(9), 2001, pp. 841-848

Abstract

The hypoxic SRP1/TIR1 gene encodes a stress-response cell wall mannoprotein and this gene is downregulated at acidic pH. The stress-responsive HOG pathway is necessary to maintain hpoxic TIR1 expression, hut only at acidic pH, However, unlike known HOG pathway-dependent genes, TIR1 is under positive cAMP control and this effect is mediated by GPA2 but not by RAS2. Geneticanalysis showed that ovd1 mutation was epistatic to the gpa2 mutation, thereby indicating that Gpa2p is needed to counteract the Ord1 factor, which is involved in the repression of hypoxic TIR1 expression, while the HOG pathway appears to be independent from Ord1 repression, In addition, an increased ORD1 gene expression was observed in the Delta gpa2 mutant cells, meaning that GPA2 maintains a low basal level of ORD1 transcripts. Thus, cAMP allo,vs partial relief of the TIR1 repression exerted by Ord1p. However, this is contradicted at acidic pH by the HOG pathway requirement because Hog1p is activated under stress conditions when the cAMP cellular content is low. The opposite effects of the GPA2-cAMP and HOG pathways are likely to explain the diminished hypoxic expression of TIR1 at acidic pH. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 05/04/20 alle ore 09:09:33