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Titolo:
The role of silver in wound healing - Part 3: Matrix metalloproteinases innormal and impaired wound healing: A potential role of nanocrystalline silver
Autore:
Kirsner, RS; Orsted, H; Wright, JB;
Indirizzi:
Univ Miami, Sch Med, Dept Epidemiol & Publ Hlth, Dept Dermatol & CutaneousSurg, Miami, FL 33152 USA Univ Miami Miami FL USA 33152 rmatol & CutaneousSurg, Miami, FL 33152 USA
Titolo Testata:
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
fascicolo: 3, volume: 13, anno: 2001, supplemento:, C
pagine: 4 - 12
SICI:
1044-7946(200105/06)13:3<4:TROSIW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE INHIBITOR; RHEUMATOID-ARTHRITIS; EXPRESSION; ULCERS; DEGRADATION; COLLAGENASE; FLUID; OSTEOARTHRITIS; PROTEINASES; GELATINASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kirsner, RS Univ Miami, Sch Med, Dept Epidemiol & Publ Hlth, Dept Dermatol& CutaneousSurg, Miami, FL 33152 USA Univ Miami Miami FL USA 33152 aneousSurg, Miami, FL 33152 USA
Citazione:
R.S. Kirsner et al., "The role of silver in wound healing - Part 3: Matrix metalloproteinases innormal and impaired wound healing: A potential role of nanocrystalline silver", WOUNDS, 13(3), 2001, pp. 4-12

Abstract

Matrix metalloproteinases (MMP) are part of a group of proteolytic enzymesthat are important in various repair and inflammatory processes. Dysregulation of MMPs and other proteinases has been linked to a number of pathologic processes, including such chronic inflammatory disorders as rheumatoid arthritis, periodontal disease, and chronic wounds. Of the proteolytic enzymes, MMPs have received the most attention with regard to wound healing. MMPsappear to be important in acute wound healing. Differences exist between the amounts, timing, and distribution of MMPs and their inhibitors (tissue inhibitor of metalloproteinases [TIMPs]) in acute and chronic wounds. This suggests that this imbalance may be important in the development and duration of chronic wounds. In fact, alteration of the MMP/TIMP ratio changes withthe healing of chronic wounds. Therapies used to treat chronic wounds may impact upon MMPs and their inhibitors, and attention to alterations of MMPswith therapy may be an important endpoint. Among those therapies that likely impact MMPs is the use of nanocystalline silver dressings. Animal studies have shown that nanocystalline silver dressings alter MMP expression. In this paper we will review MMPs, the role of MMPs in wound healing, and present preliminary data of the ability to alter MMP expression in chronic human wounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:33:29