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Titolo:
Intranasal immunisation with influenza-ISCOM induces strong mucosal as well as systemic antibody and cytotoxic T-lymphocyte responses
Autore:
Sjolander, S; Drane, D; Davis, R; Beezum, L; Pearse, M; Cox, J;
Indirizzi:
CSL Ltd, Immunol Res & Dev, Parkville, Vic 3052, Australia CSL Ltd Parkville Vic Australia 3052 Dev, Parkville, Vic 3052, Australia
Titolo Testata:
VACCINE
fascicolo: 28-29, volume: 19, anno: 2001,
pagine: 4072 - 4080
SICI:
0264-410X(20010716)19:28-29<4072:IIWIIS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-ANTIGENS ISCOMS; VACCINE DEVELOPMENT; IMMUNE-RESPONSES; CTL RESPONSES; CPG DNA; IMMUNIZATION; VIRUS; MICE; ADJUVANTS; INDUCTION;
Keywords:
influenza-ISCOM; intranasal administration; mucosal immune response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Drane, D CSL Ltd, Immunol Res & Dev, Parkville, Vic 3052, Australia CSL Ltd Parkville Vic Australia 3052 kville, Vic 3052, Australia
Citazione:
S. Sjolander et al., "Intranasal immunisation with influenza-ISCOM induces strong mucosal as well as systemic antibody and cytotoxic T-lymphocyte responses", VACCINE, 19(28-29), 2001, pp. 4072-4080

Abstract

Intranasal administration of vaccines is preferred for induction of mucosal immune responses. In this study, mice were immunised intranasally and subcutaneously with influenza-immune stimulating complexes (influenza-ISCOM), The intranasal dose was 15-times the subcutaneous dose. All mice dosed withinfluenza-ISCOMs survived challenge with live virus and comparable serum antibody and splenic cytotoxic T-lymphocyte responses were detected in both groups. Induction of mucosal IEA was significantly higher with intranasal immunisation and was comparable to responses induced with the heat labile enterotoxin of Escherichia coli as adjuvant. These findings demonstrate that intranasal administration of high dose influenza-ISCOM results in potent systemic and mucosal immune responses. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 20:00:56