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Titolo:
Immunogenicity and reactogenicity of acellular diphtheria/tetanus/pertussis vaccines given as a pre-school booster: effect of simultaneous administration of MMR
Autore:
Miller, E; Waight, P; Laurichesse, H; Andrews, N; Thornton, C; Sesardic, D; Corbel, M;
Indirizzi:
Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Immunisat Div, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ t Div, London NW9 5EQ, England Publ Hlth Lab Serv, Ctr Appl Microbiol & Res, Salisbury SP4 0JG, Wilts, England Publ Hlth Lab Serv Salisbury Wilts England SP4 0JG P4 0JG, Wilts, England Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England Natl Inst Biol Stand & Controls Potters Bar Herts England EN6 3QG England
Titolo Testata:
VACCINE
fascicolo: 28-29, volume: 19, anno: 2001,
pagine: 3904 - 3911
SICI:
0264-410X(20010716)19:28-29<3904:IAROAD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL PERTUSSIS-VACCINE; CONTROLLED TRIAL; DIPHTHERIA; TETANUS;
Keywords:
diphtheria/tetanus/perlussis vaccines; MMR; pre-school booster;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, E Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, ImmunisatDiv, 61 Colindale Ave, London NW9 5EQ, England Publ Hlth Lab Serv 61 Colindale Ave London England NW9 5EQ land
Citazione:
E. Miller et al., "Immunogenicity and reactogenicity of acellular diphtheria/tetanus/pertussis vaccines given as a pre-school booster: effect of simultaneous administration of MMR", VACCINE, 19(28-29), 2001, pp. 3904-3911

Abstract

Four acellular diphtheria/tetanus/pertussis (aDTP) vaccines were compared with two diphtheria/tetanus (DT) vaccines given as a pre-school booster to 1033 children aged 4 to < 6 years who had completed primary immunisation with DTP vaccine according to the UK 2, 3 and 4 month schedule; 71 children had received aDTP vaccine and the remaining 962 a whole cell DTP vaccine forprimary immunisation. The effect of simultanous administration of a seconddose of MMR vaccine was evaluated in 374 (37%). Overall, there was little difference in the frequency of post-vaccination symptoms in DT and aDTP vaccinees, although local reactions occurred more quickly in the aDTP group. The concomitant administration of MMR had no effect on local reactions or fever within 10 days, or on the proportions requiring a doctor's visit in the4-6 week post-vaccination period. Local reactions 2 3 cm were higher on day 2 in children who had received aDTP for primary immunisation (erythema 32.4% vs. 17.4% for wDTP, P = 0.0012; swelling 28.2% vs. 15.5%, P = 0.0027). Pertussis antibody responses were consistent with the antigen content of the aDTP vaccines. All were more immunogenic with respect to PT - the only pertussis antigen which by itself has been shown to be protective in clinicaltrials - than a wDTP pre-school booster given in an earlier trial. MMR vaccine had no significant effect on antibody responses to either the pertussis or diphtheria and tetanus antigens. Diphtheria antibody responses in children who had received wDTP for-primary immunisation were 2.8 times higher than in those who had received aDTP vaccine (P < 0.0001); they were also higher in children who had received a single dose of a Haemophilus influenzae type b vaccine containing CRM197 conjugate after 12 months of age. For countries currently using DT vaccines as a pre-school booster, replacement withan aDTP vaccine is unlikely to have a perceptable effect on reactogenicity, at least in children given wDTP for primary immunisation, and would boostantibody levels to antigens known to be associated with protection. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:24:49