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Titolo:
Experimental utility of rabies virus-neutralizing human monoclonal antibodies in post-exposure prophylaxis
Autore:
Hanlon, CA; DeMattos, CA; DeMattos, CC; Niezgoda, M; Hooper, DC; Koprowski, H; Notkins, A; Rupprecht, CE;
Indirizzi:
Ctr Dis Control & Prevent, Rabies Sect MSG33, Atlanta, GA 30333 USA Ctr Dis Control & Prevent Atlanta GA USA 30333 G33, Atlanta, GA 30333 USA Thomas Jefferson Univ, Ctr Neurovirol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA NIDR, Expt Med Sect, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA NIDR Bethesda MD USA 20892 ct & Immun Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
VACCINE
fascicolo: 28-29, volume: 19, anno: 2001,
pagine: 3834 - 3842
SICI:
0264-410X(20010716)19:28-29<3834:EUORVH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTEXPOSURE TREATMENT; IMMUNE GLOBULIN; VACCINE; FAILURE; GLYCOPROTEIN; LYSSAVIRUS; INFECTION; AUSTRALIA; THAILAND; BATS;
Keywords:
rabies; human monoclonal antibodies; lyssaviruses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Hanlon, CA Ctr Dis Control & Prevent, Rabies Sect MSG33, 1600 Clifton Rd NE, Atlanta,GA 30333 USA Ctr Dis Control & Prevent 1600 Clifton Rd NE Atlanta GA USA 30333
Citazione:
C.A. Hanlon et al., "Experimental utility of rabies virus-neutralizing human monoclonal antibodies in post-exposure prophylaxis", VACCINE, 19(28-29), 2001, pp. 3834-3842

Abstract

Rabies immune globulin (RIG) is essential for post-exposure prophylaxis but is expensive and not widely available. Rabies virus-neutralizing human monoclonal antibodies (Mabs) were evaluated in vitro and in a Syrian hamster model as a potential future alternative. Seven Mabs neutralized representative rabies virus variants. However, a European bat lyssavirus was not neutralized by either Mabs or RIG. Moreover. Duvenhage virus was neutralized by RIG, but not by Mabs, and Lagos bat and Mokola viruses were neutralized by one Mab but not by RIG. In hamsters, one Mab resulted in protection that was comparable to human RIG. These results suggest that Mabs may provide a promising alternative to RIG. 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 19:04:22