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Titolo:
The impact of donor age on liver transplantation: Influence of donor age on early liver function and on subsequent patient and graft survival
Autore:
Busquets, J; Xiol, X; Figueras, J; Jaurrieta, E; Torras, J; Ramos, E; Rafecas, A; Fabregat, J; Lama, C; Ibanez, L; Llado, L; Ramon, JM;
Indirizzi:
Univ Barcelona, Hosp Princeps Espanya, Dept Surg, Barcelona 08907, Spain Univ Barcelona Barcelona Spain 08907 , Dept Surg, Barcelona 08907, Spain Univ Barcelona, Hosp Princeps Espanya, Dept Gastroenterol, Barcelona 08907, Spain Univ Barcelona Barcelona Spain 08907 stroenterol, Barcelona 08907, Spain Univ Barcelona, Hosp Princeps Espanya, Dept Prevent Med, Barcelona 08907, Spain Univ Barcelona Barcelona Spain 08907 Prevent Med, Barcelona 08907, Spain
Titolo Testata:
TRANSPLANTATION
fascicolo: 12, volume: 71, anno: 2001,
pagine: 1765 - 1771
SICI:
0041-1337(20010627)71:12<1765:TIODAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK-FACTORS; MULTIVARIATE-ANALYSIS; HEPATIC ALLOGRAFTS; MARGINAL DONORS; COLD ISCHEMIA; UW SOLUTION; OLDER; PRESERVATION; REJECTION; RECIPIENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Figueras, J Univ Barcelona, Hosp Princeps Espanya, Dept Surg, C Feixa Llarga S-N, Barcelona 08907, Spain Univ Barcelona C Feixa Llarga S-N BarcelonaSpain 08907 Spain
Citazione:
J. Busquets et al., "The impact of donor age on liver transplantation: Influence of donor age on early liver function and on subsequent patient and graft survival", TRANSPLANT, 71(12), 2001, pp. 1765-1771

Abstract

Background. The urgent need to increase the organ donor pool has led to the expansion of criteria for donor selection. The aim of this study was to analyze the influence of donor age on early graft function, subsequent graftloss, and mortality after liver transplantation (LT),Methods, Data on LT were evaluated retrospectively in a population-based cohort of 400 LTs in 348 patients. Of these, 21 (5%) were from donors >70 years old.]Pretransplantation donor and recipient characteristics and the evolution of recipients were analyzed. The influence of donor age as a risk factor was assessed using univariate and multivariate analyses. Results. Actuarial graft survival was 89% at 1 month after LT, 81% after 6months, and 59% after 60 months. Multivariate analysis demonstrated that only donor age (>70 years old) was associated with a higher risk of long-term graft loss (relative risk [RR]=1.4, 95% confidence interval [CI]=1-1.9; P=0.03) and mortality (RR=1.7, 95% CI=1.2-2.3; P=0.01), Graft survival of septuagenarian livers was 80% at 1 month after LT, 56% after 6 months, and 25% after 54 months, Actuarial survival analysis (Kaplan-Meier curves) also demonstrated worse evolution in recipients of livers from old donors (log-rank test, P<0.001). Conclusions. Advanced donor age is associated with lower graft and recipient survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:13:45