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Titolo:
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Autore:
Rutter, J; Reick, M; Wu, LC; McKnight, SL;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 ed Ctr, Dept Biochem, Dallas, TX 75390 USA
Titolo Testata:
SCIENCE
fascicolo: 5529, volume: 293, anno: 2001,
pagine: 510 - 514
SICI:
0036-8075(20010720)293:5529<510:ROCAND>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRACHIASMATIC NUCLEUS; CIRCADIAN CLOCK; GLUCOSE-UTILIZATION; AEROBIC GLYCOLYSIS; EXPRESSION; LACTATE; BRAIN; ORGANIZATION; ASTROCYTES; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: McKnight, SL Univ Texas, SW Med Ctr, Dept Biochem, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 5390 USA
Citazione:
J. Rutter et al., "Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors", SCIENCE, 293(5529), 2001, pp. 510-514

Abstract

Clock:BMAL1 and NPAS2:BMAL1 are heterodimeric transcription factors that control gene expression as a function of the Light-dark cycle. Although built to fluctuate at or near a 24-hour cycle, the clock can be entrained by Light, activity, or food. Here we show that the DNA-binding activity of the Clock:BMAL1 and NPAS2:BMAL1 heterodimers is regulated by the redox state of nicotinamide adenine dinucleotide (NAD) cofactors in a purified system. Thereduced forms of the redox cofactors, NAD(H) and NADP(H), strongly enhanceDNA binding of the Clock:BMAL1 and NPAS2:BMAL1 heterodimers, whereas the oxidized forms inhibit. These observations raise the possibility that food, neuronal activity, or both may entrain the circadian clock by direct modulation of cellular redox state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:35:58