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Titolo:
The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis
Autore:
Boberg, KM; Spurkland, A; Rocca, G; Egeland, T; Saarinen, S; Mitchell, S; Broome, U; Chapman, R; Olerup, O; Pares, A; Rosina, F; Schrumpf, E;
Indirizzi:
Gradenigo Hosp, Dept Gastroenterol, Turin, Italy Gradenigo Hosp Turin Italy enigo Hosp, Dept Gastroenterol, Turin, Italy Univ Barcelona, Hosp Clin & Prov, Barcelona, Spain Univ Barcelona Barcelona Spain lona, Hosp Clin & Prov, Barcelona, Spain John Radcliffe Hosp, Dept Med, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Med, Oxford OX3 9DU, England Karolinska Inst, Huddinge Hosp, Dept Clin Immunol, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 unol, S-10401 Stockholm, Sweden Karolinska Inst, Huddinge Hosp, Unit Gastroenterol & Hepatol, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 atol, S-10401 Stockholm, Sweden Molinette Hosp, Dept Gastroenterol, Turin, Italy Molinette Hosp Turin Italy nette Hosp, Dept Gastroenterol, Turin, Italy Univ Oslo, Natl Hosp, Epidemiol Sect, Oslo, Norway Univ Oslo Oslo Norway niv Oslo, Natl Hosp, Epidemiol Sect, Oslo, Norway Univ Oslo, Natl Hosp, Dept Med, Inst Immunol, Oslo, Norway Univ Oslo Oslo Norway , Natl Hosp, Dept Med, Inst Immunol, Oslo, Norway
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 8, volume: 36, anno: 2001,
pagine: 886 - 890
SICI:
0036-5521(200108)36:8<886:THHGIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPID DISEASE PROGRESSION; RHEUMATOID-ARTHRITIS; NATURAL-HISTORY; HLA-DQ; CONFER SUSCEPTIBILITY; PROGNOSTIC FACTORS; SURVIVAL MODELS; TRANSPLANTATION; ADVANTAGE; ANTIGENS;
Keywords:
cholangiocarcinoma; HLA class II genes; prognostic models;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Boberg, KM Rikshosp, Dept Med, NO-0027 Oslo, Norway Rikshosp Oslo NorwayNO-0027 , Dept Med, NO-0027 Oslo, Norway
Citazione:
K.M. Boberg et al., "The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis", SC J GASTR, 36(8), 2001, pp. 886-890

Abstract

Background: An improvement of prognostic models in primary sclerosing cholangitis (PSC) is needed. In particular, inclusion of prognostic markers that are independent of the disease stage would be advantageous. We investigated whether HLA class II genes associated with PSC are also related to disease progression. Methods: Tnt: study included 265 PSC patients from five European countries with a median follow-up of 9.1 years. The end-points were death (n = 38) or liver transplantation (n = 52). Thirty patients developed cholangiocarcinoma during follow-up. Results: The DRB1*03,DQA1*0501, DQB1*02 (i.e. DR3,DQ2) heterozygous genotype was associated with an increased risk of death or liver transplantation (hazard ratio = 1.63; 95% confidence interval (CI)= 1.06-2.52). The presence of a DQ6 encoding haplotype (DQB1*0603 or DQB1*0602) in DR3,DQ? negative individuals was associated with a reduced risk of death or liver transplantation (hazard ratio = 0.57: 95% CI = 0.36-0.88). There was a trend towards an increased risk of developing cholangiocarcinoma among DR4,DQ8 positive patients, but this did not reach significance (odds ratio = 2.27; 95% CI = 0.78-6.62). Conclusion: The DR3,DQ?, heterozygous genotype is associated with a more rapid progression of PSC, whereas HLA-DQ6 is associated with a retarded disease progression. It is possible that the DR-l,DQ8 haplotype is related to cholangiocarcinoma development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:15:16