Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antibodies to Th/To ribonucleoprotein in patients with localized scleroderma
Autore:
Yamane, K; Ihn, H; Kubo, M; Kuwana, M; Asano, Y; Yazawa, N; Tamaki, K;
Indirizzi:
Univ Tokyo, Fac Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Dermatol, Bunkyo Ku, Tokyo 1138655, Japan Keio Univ, Sch Med, Inst Adv Med Res, Div Cellular Signaling, Tokyo, JapanKeio Univ Tokyo Japan Adv Med Res, Div Cellular Signaling, Tokyo, Japan
Titolo Testata:
RHEUMATOLOGY
fascicolo: 6, volume: 40, anno: 2001,
pagine: 683 - 686
SICI:
1462-0324(200106)40:6<683:ATTRIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIHISTONE ANTIBODIES; LINEAR SCLERODERMA; SYSTEMIC-SCLEROSIS; ABNORMALITIES; AUTOANTIBODY;
Keywords:
antinucleolar antibodies; immunoprecipitation; humoral immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Ihn, H Univ Tokyo, Fac Med, Dept Dermatol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655,Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 go, Tokyo 1138655,Japan
Citazione:
K. Yamane et al., "Antibodies to Th/To ribonucleoprotein in patients with localized scleroderma", RHEUMATOLOG, 40(6), 2001, pp. 683-686

Abstract

Objective. Antibodies to Th/To ribonucleoprotein (anti-Th/To) have been detected almost exclusively in patients with systemic sclerosis. Therefore, we aimed to determine the prevalence of anti-Th/To in patients with localized scleroderma. Methods. Seventy serum samples from patients with localized scleroderma were examined by RNA immunoprecipitation and indirect immunofluorescence analysis using HEp-2 cells as substrate. Results. Three (4%) of 70 sera from patients with localized scleroderma immunoprecipitated 7-2 (Th) RNA and 8-2 (To) RNA. Indirect immunofluorescenceanalysis demonstrated that all the sera positive for anti-Th/To showed mainly nucleolar staining. In one patient, the coexistence of anti-histone antibody with anti-Th/To was detected by enzyme-linked immunosorbent assay foranti-histone antibody and confirmed using an absorption test with histonesfollowed by indirect immunofluorescence analysis. Moreover, the localized scleroderma patients with anti-Th/To tended to have significantly fewer sclerotic lesions than those without. Conclusion. Anti-Th/To is one of the serological abnormalities in localized scleroderma, and the presence of anti-Th/To may be a serological indicator of a mild form of cutaneous involvement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:20:27