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Titolo:
Effects of the American College of Rheumatology systemic sclerosis trial guidelines on the nature of systemic sclerosis patients entering a clinical trial
Autore:
Furst, DE; Clements, PJ; Wong, WK; Mayes, MD; Wigley, F; White, B; Weisman, M; Barr, W; Moreland, L; Martin, R; Medsger, TA; Steen, V; Collier, D; Weinstein, A; Lally, E; Varga, J; Weiner, SR; Andrews, B; Abeles, M; Peter, JB; Seibold, JR;
Indirizzi:
Virginia Mason Res Ctr, Arthrit Clin Res Unit, Seattle, WA 98101 USA Virginia Mason Res Ctr Seattle WA USA 98101 s Unit, Seattle, WA 98101 USA Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Hutzel Hosp, Dept Rheumatol, Detroit, MI 48201 USA Hutzel Hosp Detroit MIUSA 48201 p, Dept Rheumatol, Detroit, MI 48201 USA Johns Hopkins Univ, Dept Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ns Univ, Dept Med, Baltimore, MD USA Univ Calif San Diego, Dept Med, Ctr Med, La Jolla, CA 92093 USA Univ CalifSan Diego La Jolla CA USA 92093 tr Med, La Jolla, CA 92093 USA Univ Maryland, Sch Med, Dept Med, College Pk, MD 20742 USA Univ Maryland College Pk MD USA 20742 Dept Med, College Pk, MD 20742 USA Loyola Univ, Stritch Sch Med, Dept Med, New Orleans, LA 70118 USA Loyola Univ New Orleans LA USA 70118 Dept Med, New Orleans, LA 70118 USA Univ Alabama, Dept Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , Dept Med, Birmingham, AL 35294 USA Michigan State Univ, Coll Med, Dept Med, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 t Med, E Lansing, MI 48824 USA Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Sch Med, Dept Med, Pittsburgh, PA USA Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ept Med, Washington, DC 20007 USA Univ Colorado, Denver Hlth Med Ctr, Dept Rheumatol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 Dept Rheumatol, Boulder, CO 80309 USA George Washington Univ, Med Ctr, Dept Med, Washington, DC 20052 USA GeorgeWashington Univ Washington DC USA 20052 , Washington, DC 20052 USA Brown Univ, Sch Med, Dept Med, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 ed, Dept Med, Providence, RI 02912 USA Univ Illinois, Rheumatol Sect, Chicago, IL USA Univ Illinois Chicago IL USA v Illinois, Rheumatol Sect, Chicago, IL USA Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ine, Dept Med, Irvine, CA 92717 USA Univ Connecticut, Ctr Hlth, Dept Med, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 Hlth, Dept Med, Storrs, CT 06269 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Scleroderma Program, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 gram, Newark, NJ 07103 USA
Titolo Testata:
RHEUMATOLOGY
fascicolo: 6, volume: 40, anno: 2001,
pagine: 615 - 622
SICI:
1462-0324(200106)40:6<615:EOTACO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; DIFFUSE SCLERODERMA; PLACEBO; MULTICENTER; ABNORMALITIES; CYCLOFENIL;
Keywords:
systemic sclerosis; scleroderma; organ involvement; ACR guidelines for systemic sclerosis trials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Furst, DE Virginia Mason Res Ctr, Arthrit Clin Res Unit, 1000 Seneca St, Seattle, WA98101 USA Virginia Mason Res Ctr 1000 Seneca St Seattle WA USA 98101 1 USA
Citazione:
D.E. Furst et al., "Effects of the American College of Rheumatology systemic sclerosis trial guidelines on the nature of systemic sclerosis patients entering a clinical trial", RHEUMATOLOG, 40(6), 2001, pp. 615-622

Abstract

Objectives. To compare the systemic sclerosis (SSc) patients entered into the D-penicillamine trial with SSc patients entered into previous controlled SSc trials. It was hypothesized that the D-penicillamine trial patients, who conformed to the American College of Rheumatology (ACR) guidelines for clinical trials in SSc were different from patients entered into previous trials. Methods. Patients entering a double-blind, randomized trial of low- vs high-dose D-penicillamine were described carefully and completely. Their characteristics were then compared with previously published data on SSc and itstreatment. Results. One hundred and thirty-four patients had early [mean duration 9.5(S.D. 4.2) months], diffuse [skin score 21 (8)] disease. Organ involvementin the patients was as follows: pulmonary 54%, cardiac 20%, joints 38%, muscular 20%. Thirty-three per cent had mild proteinuria and 13% were hypertensive when first seen. Compared with patients in most previous studies, these SSc patients had earlier disease and uniformly had diffuse disease. Theyhad less muscular involvement, less dyspnoea, less abnormal pulmonary function and less cardiac and less renal involvement than patients in earlier studies. Conclusions. The use of the new ACR guidelines for SSc trials may change the nature of patient populations entering future studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:34:15