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Titolo:
Neural signals that regulate GnRH neurones directly during the oestrous cycle
Autore:
Smith, MJ; Jennes, L;
Indirizzi:
Univ Kentucky, Sch Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Sch Med, Dept Physiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 ept Physiol, Lexington, KY 40536 USA
Titolo Testata:
REPRODUCTION
fascicolo: 1, volume: 122, anno: 2001,
pagine: 1 - 10
SICI:
1470-1626(200107)122:1<1:NSTRGN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; ESTROGEN-RECEPTOR-ALPHA; VASOACTIVE-INTESTINAL-PEPTIDE; MESSENGER-RIBONUCLEIC-ACID; EXCITATORY AMINO-ACIDS; INDUCED LH SURGE; LUTEINIZING-HORMONE; FEMALE RAT; PREOPTIC AREA; PROLACTIN SURGES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Jennes, L Univ Kentucky, Sch Med, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 l, Lexington, KY 40536 USA
Citazione:
M.J. Smith e L. Jennes, "Neural signals that regulate GnRH neurones directly during the oestrous cycle", REPRODUCT, 122(1), 2001, pp. 1-10

Abstract

GnRH, produced by a loose network of neurones in the basal forebrain, is the primary brain signal responsible for the release of LH and FSH from the anterior pituitary gland. The ovarian steroid hormone oestradiol feeds backat both the central nervous system and the anterior pituitary to regulate the patterns of release of GnRH and the gonadotrophins. Although recent evidence indicates that oestradiol may act directly on some GnRH neurones through classical genomic mechanisms, data from published studies have demonstrated that neurotransmission of afferent neuronal systems that are receptiveto oestradiol is necessary to drive reproductive cyclicity. Many classicalneurotransmitters and neuropeptides alter GnRH neuronal activity, through direct and sometimes indirect actions. This review focuses on the neurotransmitters that regulate GnRH neurones by binding to and activating specific membrane receptors that are expressed in GnRH neurones. These include the catecholamines, gamma -aminobutyric acid, glutamate, neuropeptide Y, neurotensin, beta -endorphin and vasoactive intestinal polypeptide. On the basis of recent molecular and neuroanatomical evidence, it is proposed that oestradiol influences the activity of these neurotransmitter and neuropeptide systems within the GnRH network to drive reproductive cyclicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:01:53