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Titolo:
Narcoleptic canines display periodic leg movements during sleep
Autore:
Okura, M; Fujiki, N; Ripley, B; Takahashi, S; Amitai, N; Mignot, E; Nishino, S;
Indirizzi:
Stanford Univ, Dept Psychiat & Behav Sci, Sleep Res Ctr, Ctr Narcolepsy, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 Narcolepsy, Palo Alto, CA 94304 USA
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 55, anno: 2001,
pagine: 243 - 244
SICI:
1323-1316(200106)55:3<243:NCDPLM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISORDER;
Keywords:
A11; animal model; dogs; dopamine agonists; dopamine D2/D3 receptor; hypocretin; narcolepsy; orexin; periodic leg movements during sleep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Nishino, S Stanford Univ, Dept Psychiat & Behav Sci, Sleep Res Ctr, Ctr Narcolepsy, 1201 Welch Rd,MSLS Bldg Room P113, Palo Alto, CA 94304 USA Stanford Univ 1201 Welch Rd,MSLS Bldg Room P113 Palo Alto CA USA 94304
Citazione:
M. Okura et al., "Narcoleptic canines display periodic leg movements during sleep", PSY CLIN N, 55(3), 2001, pp. 243-244

Abstract

Periodic leg movements during sleep (PLMS) is a high prevalent sleep disorder of unknown etiology. The disease is pharmacologically treated with dopaminergic agonists (i.e. D2/D3 agonists) and opiates. Periodic leg movementsduring sleep often occur in narcoleptic patients. We observed that narcoleptic canines, like narcoleptic humans, also exhibit jerky, unilateral or bilateral slow leg movements during sleep. The movements in dogs are characterized by repetitive dorsiflexions of the ankle, lasting 0.5-1.5 s, and occur at regular intervals of 3-20 s, thus showing similarities to PLMS in humans. The observation that D2/D3 agonists aggravate cataplexy in narcoleptic dogs suggests that altered dopaminergic regulation in canine narcolepsy mayplay a critical role in both cataplexy and PLMS. Our canines may thereforebe an invaluable resource in PLMS research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:37:44