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Titolo:
The effects of flumazenil on sleepiness, task performance and nocturnal sleep after anesthesia with midazolam
Autore:
Ozone, M; Itoh, H; Ohbuchi, K; Ohyama, E; Hayashida, K; Sato, M; Sasaki, M; Ushijima, S; Tanifuji, Y;
Indirizzi:
Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, Tokyo, Japan Jikei Univ Tokyo Japan Sch Med, Dept Psychiat, Minato Ku, Tokyo, Japan Jikei Nursing Sch, Tokyo, Japan Jikei Nursing Sch Tokyo JapanJikei Nursing Sch, Tokyo, Japan Jikei Univ, Sch Med, Dept Anaesthesiol, Tokyo, Japan Jikei Univ Tokyo Japan i Univ, Sch Med, Dept Anaesthesiol, Tokyo, Japan
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 55, anno: 2001,
pagine: 235 - 237
SICI:
1323-1316(200106)55:3<235:TEOFOS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Keywords:
day surgery; flumazenil; midazolam; recovery; slow wave sleep; subjective sleepiness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
2
Recensione:
Indirizzi per estratti:
Indirizzo: Ozone, M Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, 3-25-8 Nishi Shinbashi, Tokyo, Japan Jikei Univ 3-25-8 Nishi Shinbashi Tokyo Japan shi, Tokyo, Japan
Citazione:
M. Ozone et al., "The effects of flumazenil on sleepiness, task performance and nocturnal sleep after anesthesia with midazolam", PSY CLIN N, 55(3), 2001, pp. 235-237

Abstract

The purpose of the present study was to clarify the changes in psychophysiological functions after anesthesia with midazolam (intravenous (i.v.) benzodiazepine anesthetic) and to examine the ability of flumazenil (benzodiazepine antagonist) to prevent the adverse effects of anesthesia with midazolam. Clinical dose of midazolam (0.1 mg/kg i.v,) was administered to seven healthy volunteers and either flumazenil (0.3 mg i.v.) or saline was injectedat the end of the anesthesia. After anesthesia with midazolam, subjective sleepiness and euphoria increased significantly, but these changes were notobserved when flumazenil was administered. In addition. sleep latency was prolonged and sleep efficiency decreased significantly after midazolam anesthesia with and without flumazenil. Slow wave sleep decreased significantlyonly by co-administration of flumazenil.

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Documento generato il 06/04/20 alle ore 02:07:29