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Titolo:
A pilot study analyzing PSA, serum testosterone, lipid profile, body mass index and race in a small sample of patients with and without carcinoma of the prostate
Autore:
Mydlo, JH; Tieng, NL; Volpe, MA; Chaiken, R; Kral, JG;
Indirizzi:
Temple Univ, Sch Med, Dept Urol, Philadelphia, PA 19122 USA Temple Univ Philadelphia PA USA 19122 pt Urol, Philadelphia, PA 19122 USA SUNY Downstate Med Sch, Dept Urol, Brooklyn, NY USA SUNY Downstate Med Sch Brooklyn NY USA Sch, Dept Urol, Brooklyn, NY USA SUNY Downstate Med Sch, Dept Endocrinol, Brooklyn, NY USA SUNY Downstate Med Sch Brooklyn NY USA Dept Endocrinol, Brooklyn, NY USA SUNY Downstate Med Sch, Dept Surg, Brooklyn, NY USA SUNY Downstate Med Sch Brooklyn NY USA Sch, Dept Surg, Brooklyn, NY USA
Titolo Testata:
PROSTATE CANCER AND PROSTATIC DISEASES
fascicolo: 2, volume: 4, anno: 2001,
pagine: 101 - 105
SICI:
1365-7852(2001)4:2<101:APSAPS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNITED-STATES; WHITE MEN; AFRICAN-AMERICAN; CANCER RISK; OBESITY; BLACK; ANDROGENS; SURVIVAL; ANTIGEN; HEALTH;
Keywords:
body mass index; prostate cancer; testosterone; race;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mydlo, JH Temple Univ Hosp, Dept Urol, Suite 350,Parkinson Pavil,Broad & Ontario St,Philadelphia, PA 19140 USA Temple Univ Hosp Suite 350,Parkinson Pavil,Broad & Ontario St Philadelphia PA USA 19140
Citazione:
J.H. Mydlo et al., "A pilot study analyzing PSA, serum testosterone, lipid profile, body mass index and race in a small sample of patients with and without carcinoma of the prostate", PROSTATE C, 4(2), 2001, pp. 101-105

Abstract

Androgens, diet, race and obesity are thought to play some roles in the pathogenesis of prostate cancer. We wanted to evaluate if there were any interrelationships between prostate specific antigen (PSA), serum testosterone,serum cholesterol, HDL, triglycerides, body mass index (BMI) and race, in older patients with and without prostate cancer (CaP). We evaluated 308 patients referred to urologists in private practice offices and clinics with and without prostate cancer with regard to race, serum PSA, age, serum testosterone, full lipid profile, height and weight, and stage of cancer. We used multivariate analysis, Fisher's exact test and t-tests as well as logistic regression analysis. Data was analyzed using SPSS computer software, and P-values < 0.05 were considered statistically significant. Significantly higher levels of serum testosterone were found in black men with Cap than black men without Cap (526 +/- 28 vs 404 +/- 19, respectively. ) We also found significantly higher levels of serum testosterone in white men with CaP than white men without Cap (409 +/- 20 vs 302 +/- 14, respectively, P < 0.05). HDL was higher in black men than white men, and triglycerides were higher in white men than black men. Cholesterol was similar across all groups, butBMI was highest in white men with Cap We also found a significant association between BMI and pathological stage of prostate cancer patients among both black and white men (P < 0.05). Our study demonstrated that black men who developed Cap had higher serum testosterone levels, on average, than white men who developed Cap Furthermore, BMI was highest in white men developing CaP compared to black men, but we found a significant association betweenpathological stage and BMI in both black and white patients. Although it is controversial whether obesity is considered to be a risk factor for prostate cancer, this small pilot study suggests that BMI may play a role in theprogression of the disease once it is established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 11:53:05