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Titolo:
Prostate cancer chemoprevention agents exhibit selective activity against early stage prostate cancer cells
Autore:
Liu, YQ; Kyle, E; Patel, S; Housseau, F; Hakim, F; Lieberman, R; Pins, M; Blagosklonny, MV; Bergan, RC;
Indirizzi:
Northwestern Univ, Div Hematol Oncol, Dept Med, Sch Med, Chicago, IL 60611USA Northwestern Univ Chicago IL USA 60611 Med, Sch Med, Chicago, IL 60611USA Northwestern Univ, Robert H Lurie Canc Ctr, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 ie Canc Ctr, Chicago, IL 60611 USA NCI, Med Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Med Branch, NIH, Bethesda, MD 20892 USA NCI, Surg Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Surg Branch, NIH, Bethesda, MD 20892 USA NCI, Div Canc Prevent, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 , Div Canc Prevent, NIH, Bethesda, MD 20892 USA Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA Northwestern Univ, Robert H Lurie Canc Ctr, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 ie Canc Ctr, Chicago, IL 60611 USA
Titolo Testata:
PROSTATE CANCER AND PROSTATIC DISEASES
fascicolo: 2, volume: 4, anno: 2001,
pagine: 81 - 91
SICI:
1365-7852(2001)4:2<81:PCCAES>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; POLYMERASE CHAIN-REACTION; TYROSINE KINASE-ACTIVITY; FOCAL ADHESION KINASE; TRANSFORMING GROWTH-FACTOR-BETA-1; ANDROGEN RECEPTOR; IMMUNOHISTOCHEMICAL LOCALIZATION; MOLECULAR-BIOLOGY; EPITHELIAL-CELLS; LINES;
Keywords:
prostate cancer; chemoprevention; preclinical models; cell growth; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Bergan, RC Northwestern Univ, Div Hematol Oncol, Dept Med, Sch Med, 710 N Fairbanks,Olson 8524, Chicago, IL 60611 USA Northwestern Univ 710 N Fairbanks,Olson 8524 Chicago IL USA 60611
Citazione:
Y.Q. Liu et al., "Prostate cancer chemoprevention agents exhibit selective activity against early stage prostate cancer cells", PROSTATE C, 4(2), 2001, pp. 81-91

Abstract

Preclinical models for the identification of prostate cancer chemoprevention agents are lacking. Based upon the notion that clinically useful chemoprevention agents should exhibit selective activity against early stage disease, studies were undertaken to assess whether chemoprevention agents selectively inhibited the growth of early stage prostate cancer, as compared to late stage cancer. First, a series of cell and molecular studies were performed, which, when taken together, validated the use of a panel of prostate cell lines as a model of the different stages of carcinogenesis. Next, therapeutic responsiveness to ten different cytotoxic or chemoprevention agents was evaluated. Chemoprevention agents exhibited selective activity against normal and early transformed prostate tissue, whereas cytotoxic agents werenon-specific. Selective activity against early versus advanced prostate cancer cells is identified as a potential screening method for chemoprevention agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:38:52