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Titolo:
PEAZ-1: A new human prostate neoplastic epithelial cell line
Autore:
Schmelz, M; Cress, AE; Barrera, J; McDaniel, KM; Davis, TL; Fuchs, L; Dalkin, BL; Nagle, RB;
Indirizzi:
Univ Arizona, Hlth Sci Ctr, Dept Pathol, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 i Ctr, Dept Pathol, Tucson, AZ 85724 USA Univ Arizona, Hlth Sci Ctr, Dept Radiat Oncol, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Dept Radiat Oncol, Tucson, AZ 85724 USA Univ Arizona, Hlth Sci Ctr, Dept Surg, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Sci Ctr, Dept Surg, Tucson, AZ 85724 USA
Titolo Testata:
PROSTATE
fascicolo: 2, volume: 48, anno: 2001,
pagine: 79 - 92
SICI:
0270-4137(20010701)48:2<79:PANHPN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEINS; ADHESION MOLECULE UVOMORULIN; ANDROGEN-RECEPTOR GENE; BETA-CATENIN; E-CADHERIN; INTEGRIN DISTRIBUTION; EXTRACELLULAR-MATRIX; CANCER STATISTICS; MAMMALIAN-CELLS; CARCINOMA-CELLS;
Keywords:
prostate; in vitro cell culture; cadherins; catenins; integrins; laminin 5; androgens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Schmelz, M Univ Arizona, Hlth Sci Ctr, Dept Pathol, POB 24-5043,1501 N Campbell Ave, Tucson, AZ 85724 USA Univ Arizona POB 24-5043,1501 N Campbell Ave Tucson AZ USA 85724
Citazione:
M. Schmelz et al., "PEAZ-1: A new human prostate neoplastic epithelial cell line", PROSTATE, 48(2), 2001, pp. 79-92

Abstract

BACKGROUND. The generation of prostatic cell lines provides in vitro models for experimental studies of the pathogenesis of prostate carcinoma. Therefore, we established and characterized a new human prostate epithelial cellline, PEAZ-1 (prostate epithelial Arizona-1). METHODS. The PEAZ-1 cells were grown from a primary human prostate carcinoma specimen obtained from radical prostatectomy. The isolated cells were characterized by immunobiochemistry, immunohistochemistry, and tumorigenicitystudies. RESULTS. PEAZ-1 cells are near diploid, tumorigenic, and androgen independent for cell growth. PEAZ-1 cells express N-cadherin, alpha- and beta -catenins, and p120 at cell-cell contacts, cytoplasmic laminin 5, vinculin, paxillin, and phosphotyrosine at focal adhesions, vimentin, and cytokcratins 8 and 18. They do not express plakoglobin, E-cadherin, and PSA, and do not form desmosomes and hemidesomomes. PEAZ-1 respond to ocadaic acid, a pro-apoptotic agent, by expression of p53. CONCLUSIONS. PEAZ-1 cells is a human prostate cancer cell line that has a number of mescnchymal characteristics. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:46:22