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Titolo:
Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality
Autore:
Mazat, L; Lafont, S; Berr, C; Debuire, B; Tessler, JF; Dartigues, JF; Baulieu, EE;
Indirizzi:
Univ Bordeaux 2, Inst Natl Sante & Rech Med U330 Epidemiol Sante P, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 ante P, F-33076 Bordeaux, France Hop La Pitie Salpetriere, Rech Epidemiol Neurol & Psychopathol, Inst Natl Sante & Rech Med U360, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 U360, F-75651 Paris 13, France Hop Bicetre, Inst Natl Sante & Rech Med U488 Steroides & Syst, F-94276 Le Kremlin Bicetre, France Hop Bicetre Le Kremlin Bicetre France F-94276 Le Kremlin Bicetre, France Hop Paul Brousse, Serv Biochim, F-94808 Villejuif, France Hop Paul Brousse Villejuif France F-94808 him, F-94808 Villejuif, France
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 14, volume: 98, anno: 2001,
pagine: 8145 - 8150
SICI:
0027-8424(20010703)98:14<8145:PMODSI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE-AGED MEN; PLASMA DEHYDROEPIANDROSTERONE; CIGARETTE-SMOKING; DEHYDROISOANDROSTERONE SULFATE; POSTMENOPAUSAL WOMEN; ADRENAL ANDROGENS; SEX-DIFFERENCES; LONG-TERM; REPLACEMENT; ESTROGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mazat, L Univ Bordeaux 2, Inst Natl Sante & Rech Med U330 Epidemiol Sante P, 146 Rue Leo Saignat, F-33076 Bordeaux, France Univ Bordeaux 2 146 Rue Leo Saignat Bordeaux France F-33076 ance
Citazione:
L. Mazat et al., "Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality", P NAS US, 98(14), 2001, pp. 8145-8150

Abstract

The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agi es) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in women, a decrease with age and, among men, a negative correlation between the DHEAS level and mortality at 2 and 4 years. Here, with an 8-year followup in 290 subjects, we show a global decrease of 2.3% per year for men and 3.9% per year for women. However, in approximately 30% of cases, there was an increase of DHEAS. We observed no relationship between the evolution of DHEAS level and functional, psychological, and mental status, possibly because of selection by death. In women, no association was found between mortality and DHEAS level. In men, the relative risk (RR) of death was higher for the lowest levels of DHEAS (RR = 1.9, P = 0.007), with RR= 6.5, P = 0.003 for those under 70 years old, a result indicating heterogeneity of the population. There was an effect of subjective health on mortality that disappeared after adjustment of DHEAS levels, suggesting its relation with these DHEAS levels. Death RR was much higher in smokers with a low DHEAS level than in nonsmokers with high DHEAS (RR = 6.7, P = 0.001). We submit that the involvement of DHEAS is possibly different according to gender, that association between low DHEAS level and mortality only for men under 70 years old possibly reflects heterogeneity of the population, and that DHEAS level is a reliable predictor of death in male smokers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:20:20