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Titolo:
Two distinct mechanisms are involved in stent thrombosis under flow conditions
Autore:
Eto, K; Goto, S; Shimazaki, T; Sakakibara, M; Yoshida, M; Isshiki, T; Handa, S;
Indirizzi:
Tokai Univ, Div Cardiol, Dept Med, Sch Med, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Med, Sch Med, Kanagawa 2591193, Japan Teikyo Univ, Sch Med, Dept Med, Tokyo 173, Japan Teikyo Univ Tokyo Japan173 yo Univ, Sch Med, Dept Med, Tokyo 173, Japan
Titolo Testata:
PLATELETS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 228 - 235
SICI:
0953-7104(200106)12:4<228:TDMAII>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; PLATELET MEMBRANE GLYCOPROTEIN; VONWILLEBRAND-FACTOR-BINDING; IIB-IIIA COMPLEX; SHEAR-STRESS; MONOCLONAL-ANTIBODIES; ENHANCES THROMBOLYSIS; IIB/IIIA COMPLEX; BLOOD-FLOW; AGGREGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Goto, S Tokai Univ, Div Cardiol, Dept Med, Sch Med, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 h Med, Kanagawa 2591193, Japan
Citazione:
K. Eto et al., "Two distinct mechanisms are involved in stent thrombosis under flow conditions", PLATELETS, 12(4), 2001, pp. 228-235

Abstract

The mechanism of stent thrombosis was evaluated by a flow chamber model. APalmaz-Schatz stent was placed on glass surfaces coated with type I collagen in a parallel-plate flow chamber. Platelets were rendered fluorescent with mepacrine and whole blood was perfused through the chamber. Platelet thrombi formed around the implanted stents were continuously recorded by epi-fluorescent video-microscopy, Platelet thrombi appeared on the collagen surface within a few minutes in the absence of function blocking monoclonal antibodies. Antibody blocking vWF interaction with GP Ib alpha completely inhibited the platelet thrombi around the stent, but had no effect on platelet thrombus formation in the space between the stents and collagen, while bothwere inhibited by anti-GP IIb/IIIa. Our results suggest that two distinct mechanisms, one mediated by vWF interaction with GP Ib alpha occurring at high shear rates, and the other mediated exclusively by GP IIb/IIIa occurring at low shear rates, are involved in the process of platelet thrombus formation in the presence of stents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:01:32