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Titolo:
Intrinsic and environmental influences on immune senescence in the aged monkey
Autore:
Coe, CL; Ershler, WB;
Indirizzi:
Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Psychol, Madison, WI 53706 USA Inst Adv Studies Aging, Washington, DC USA Inst Adv Studies Aging Washington DC USA udies Aging, Washington, DC USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 73, anno: 2001,
pagine: 379 - 384
SICI:
0031-9384(200106)73:3<379:IAEIOI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; RHESUS-MONKEYS; PSYCHOSOCIAL FACTORS; NONHUMAN-PRIMATES; OLDER ADULTS; HUMANS; STRESS; YOUNG; INTERLEUKIN-2; IMPAIRMENT;
Keywords:
aging; immunity; monkey; natural killer activity; immune senescence; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Coe, CL Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706USA Univ Wisconsin 1202 W Johnson St Madison WI USA 53706 WI 53706 USA
Citazione:
C.L. Coe e W.B. Ershler, "Intrinsic and environmental influences on immune senescence in the aged monkey", PHYSL BEHAV, 73(3), 2001, pp. 379-384

Abstract

Several factors associated with the age-related decline in immunity were examined in three studies on aged rhesus monkeys. Natural killer (NK) cell activity was found to be low in many monkeys after 20 years of age, but exceptionally long-lived animals, older than 25 years, often had vigorous cytolytic responses. When NK activity was decreased in an aged monkey, it was predictive of fewer years of survival and a younger age at death, This prediction of mortality was associated with one nonimmune biomarker of aging in the monkey: nail growth rate. Monkeys with very slow nail growth and low NK activity were likely to die sooner. Although these: findings might suggest an immutable course for the aging process, the housing conditions of old monkeys also had a pronounced effect on their NK activity. The highest NK responses were: Found in old monkeys housed with just one other old animal when compared to living alone or with just a young, juvenile monkey. It remains to be determined whether this type of psychosocial influence could have asustained effect on immunity and ultimately change the pace of aging and time to mortality. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 25/01/20 alle ore 09:33:57