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Titolo:
Role of environmental factors on brain development and nerve growth factorexpression
Autore:
Cirulli, F;
Indirizzi:
Ist Super Sanita, Lab Fisiopatol Organo & Sistema, Behav Pathophysiol Sect, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 thophysiol Sect, I-00161 Rome, Italy
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 73, anno: 2001,
pagine: 321 - 330
SICI:
0031-9384(200106)73:3<321:ROEFOB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; FACTOR MESSENGER-RNA; CORTICOTROPIN-RELEASING FACTOR; GLUCOCORTICOID RECEPTOR GENE; MATERNAL-DEPRIVATION; RAT HIPPOCAMPUS; NEUROTROPHIC FACTOR; NEURONAL PLASTICITY; STRESS RESPONSES; VISUAL-CORTEX;
Keywords:
maternal separation; social regulation; corticosterone; NGF; CNS development; stress; psychopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Cirulli, F Ist Super Sanita, Lab Fisiopatol Organo & Sistema, Behav Pathophysiol Sect, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 aly
Citazione:
F. Cirulli, "Role of environmental factors on brain development and nerve growth factorexpression", PHYSL BEHAV, 73(3), 2001, pp. 321-330

Abstract

Numerous evidences suggest that early life events can affect the development of the nervous system. contributing in shaping interindividual differences in vulnerability to stress or psychopathology. A number of studies have shown that mothering style in rodents can produce neuroendocrine, neurochemical, and behavioral changes in the adult, although the basic mechanisms initiating this cascade of events still need to be investigated. This paper reviews research performed in our and other laboratories investigating some of the features characterizing hypothalamic-pituitary-adrenal (HPA) axis activity of rodents during early development, with a special emphasis on extrinsic, social regulatory factors, such as the mother and the siblings. In addition, a possible role for neurotrophins as mediators of the effects of external manipulations on brain development is suggested. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:28:50