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Titolo:
Persistent suppression of ethanol self-administration by brief social stress in rats and increased startle response as index of withdrawal
Autore:
van Erp, AMM; Miczek, KA;
Indirizzi:
Tufts Univ, Dept Psychol, Medford, MA 02155 USA Tufts Univ Medford MA USA02155 Univ, Dept Psychol, Medford, MA 02155 USA Tufts Univ, Dept Psychiat, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Univ, Dept Psychiat, Boston, MA 02111 USA Tufts Univ, Dept Pharmacol, Boston, MA 02111 USA Tufts Univ Boston MA USA02111 Univ, Dept Pharmacol, Boston, MA 02111 USA Tufts Univ, Dept Neurosci, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Univ, Dept Neurosci, Boston, MA 02111 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 73, anno: 2001,
pagine: 301 - 311
SICI:
0031-9384(200106)73:3<301:PSOESB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE; ULTRASONIC VOCALIZATIONS; AVERSIVE-STIMULATION; ALCOHOL-CONSUMPTION; COCAINE; BEHAVIOR; SUCROSE; INTOXICATION; MAINTENANCE; DEPRIVATION;
Keywords:
alcohol; self-administration; social stress; withdrawal; acoustic startle; behavior; operant conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Miczek, KA Tufts Univ, Dept Psychol, Bacon Hall,530 Boston Ave, Medford, MA 02155 USA Tufts Univ Bacon Hall,530 Boston Ave Medford MA USA 02155 5 USA
Citazione:
A.M.M. van Erp e K.A. Miczek, "Persistent suppression of ethanol self-administration by brief social stress in rats and increased startle response as index of withdrawal", PHYSL BEHAV, 73(3), 2001, pp. 301-311

Abstract

Excessive alcohol drinking is often linked to the experience of stress, but experimental approaches using animal models of alcohol self-administration have had widely varying outcomes. The objective was to determine how daily exposure to brief predictable social stress would change alcohol self-administration in rats in a daily limited access protocol. Male Long-Evans rats had either access to a 10% ethanol solution for 15 min in the home cage setting (n = 20) or were reinforced with 15% ethanol deliveries for every fifth lever press (n = 10). Subsequently, all rats were subjected to brief social stress for five consecutive days. Social stress consisted of attacks by an opponent for 5 min followed by exposure to threats while in a protective cage for 30 min. In both the home cage drinking and operant conditioninggroups, social stress exposure significantly decreased alcohol intake or rate of alcohol reinforcements, respectively. When alcohol intake was scheduled immediately before social stress (i.e., 24 h after the previous social stress episode), a decrease was observed with a delay of 1 or 2 days. When alcohol intake was scheduled 4 h after stress, no changes in intake or alcohol reinforcements were observed. Animals that consumed a low dose of ethanol displayed less defensive behavior during social stress compared to water-drinking animals, and showed an increased startle reflex at 8 and 56 h after discontinuation of daily ethanol access. The current experimental protocols of social defeat stress reveal a transient suppression rather than a facilitation of alcohol consumption. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 28/01/20 alle ore 15:29:09