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Titolo:
The haemodynamic effects of losartan after right ventricle infarct in young pigs
Autore:
Spalding, M; Ala-Kokko, T; Kiviluoma, K; Ruskoaho, H; Alahuhta, S;
Indirizzi:
Univ Hosp Oulu, Dept Anaesthesiol, FIN-90220 Oulu, Finland Univ Hosp OuluOulu Finland FIN-90220 esthesiol, FIN-90220 Oulu, Finland Univ Oulu, Bioctr Oulu, Dept Pharmacol & Toxicol, Oulu, Finland Univ OuluOulu Finland tr Oulu, Dept Pharmacol & Toxicol, Oulu, Finland
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 6, volume: 88, anno: 2001,
pagine: 325 - 330
SICI:
0901-9928(200106)88:6<325:THEOLA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; II RECEPTOR ANTAGONISM; HEART-FAILURE; MYOCARDIAL-INFARCTION; RATS; BLOCKADE; INHIBITION; HEMODYNAMICS; PERFORMANCE; ENALAPRIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Spalding, M Univ Hosp Oulu, Dept Anaesthesiol, Kajaanintie 50, FIN-90220 Oulu, Finland Univ Hosp Oulu Kajaanintie 50 Oulu Finland FIN-90220 Finland
Citazione:
M. Spalding et al., "The haemodynamic effects of losartan after right ventricle infarct in young pigs", PHARM TOX, 88(6), 2001, pp. 325-330

Abstract

The effect of an intravenous bolus injection of the type 1 angiotensin II receptor antagonist, losartan on haemodynamics after right heart infarct was studied in an experimental setting. Right heart infarct was induced in twelve young swine and losartan was given in a bolus intravenous dose one hr later to five animals, while seven animals served as controls. Haemodynamics were then followed for one hr at 15 min. intervals. Losartan was subsequently shown to decrease central venous pressure and wedge pressure, while cardiac output, left ventricle stroke work and stroke volume all showed improvement. Compared to the control animals, pulmonary vascular resistance, systemic vascular resistance and systemic pressures were unaffected by the drug, as was heart rate. The use of losartan shortly after right heart infarctreduced both right and left heart preload as well as inducing an improvement in cardiac performance. At the same time, systemic pressures and heart rate were maintained. We conclude that an inhibition of angiotensin II action may be a benefit in the treatment of right heart failure symptoms during the first hours after right heart infarct.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:25:19