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Titolo:
Dopamine transporter in vitro binding and in vivo imaging in the brain
Autore:
Bergstrom, KA; Tupala, E; Tiihonen, J;
Indirizzi:
Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70210 Med, FIN-70210 Kuopio, Finland Univ Kuopio, Niuvanniemi Hosp, Dept Forens Psychiat, FIN-70240 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70240 Psychiat, FIN-70240 Kuopio, Finland
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 6, volume: 88, anno: 2001,
pagine: 287 - 293
SICI:
0901-9928(200106)88:6<287:DTIVBA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; POSITRON-EMISSION-TOMOGRAPHY; BIOGENIC-AMINE TRANSPORTERS; MONOAMINE REUPTAKE SITES; CENTRAL-NERVOUS-SYSTEM; HIGH-AFFINITY; NEUROTRANSMITTER TRANSPORTERS; NONHUMAN-PRIMATES; NUCLEUS-ACCUMBENS; COCAINE BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Bergstrom, KA MAP Med Technol Oy, POB 9, FIN-00251 Helsinki, Finland MAP Med Technol Oy POB 9 Helsinki Finland FIN-00251 Finland
Citazione:
K.A. Bergstrom et al., "Dopamine transporter in vitro binding and in vivo imaging in the brain", PHARM TOX, 88(6), 2001, pp. 287-293

Abstract

Much research interest has lately been focused on the dopamine transporterfunction in brain. Recent findings indicate that dopamine reuptake is morelike a highly regulated than a constitutive determinant of dopamine clearance. Positron emission tomography (PET) and single-photon emission tomography (SPET) offer unique methods to study dopamine transporter function. Results from in vivo PET and SPET studies correspond well with in vitro studiesperformed on post mortem human brain tissue. Considering some of the variances between in vitro and in vivo receptor binding phenomena it may be thatthe role of a compound to alter binding to monoamine uptake sites in vitrodoes not indicate its potential to affect monoamine transporters after administration in vivo. This discrepancy may be better understood taking into account recant studies indicating the possibility of a rapid regulation of transporter function and surface expression. Furthermore, the dopamine transporter is a fruitful target for CNS drug discovery Fundamental nature of drug actions in vivo may be studied using demonstrated in vitro and in vivo imaging methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:16:46