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Titolo:
PACAP activates PKA, PKC and Ca2+ signaling cascades in rat neuroepithelial cells
Autore:
Zhou, CJ; Yada, T; Kohno, D; Kikuyama, S; Suzuki, R; Mizushima, H; Shioda, S;
Indirizzi:
Showa Univ, Sch Med, Dept Anat, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 Anat, Shinagawa Ku, Tokyo 1428555, Japan Waseda Univ, Sch Educ, Dept Biol, Shinjuku Ku, Tokyo 1698050, Japan WasedaUniv Tokyo Japan 1698050 Biol, Shinjuku Ku, Tokyo 1698050, Japan Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan
Titolo Testata:
PEPTIDES
fascicolo: 7, volume: 22, anno: 2001,
pagine: 1111 - 1117
SICI:
0196-9781(200107)22:7<1111:PAPPAC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; RECEPTOR MESSENGER-RNA; ADENYLATE-CYCLASE; POLYPEPTIDE PACAP; PAC(1) RECEPTOR; SPLICE VARIANTS; EMBRYONIC EXPRESSION; INSULIN-SECRETION; BINDING-SITES; PITUITARY;
Keywords:
PACAP; G-protein-coupled receptor; alternative splicing variants; cAMP/protein kinase A cascades; phospholipase C/protein kinase C cascade cytosolic Ca2+ concentration; development; neural fold; primitive streak stage; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Shioda, S Showa Univ, Sch Med, Dept Anat, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428555 o 1428555, Japan
Citazione:
C.J. Zhou et al., "PACAP activates PKA, PKC and Ca2+ signaling cascades in rat neuroepithelial cells", PEPTIDES, 22(7), 2001, pp. 1111-1117

Abstract

Several studies have reported that the PAC, receptor (PAC1-R), the specific receptor for PACAP, is expressed at early developmental stages. Here, we describe that the cytosolic Ca2+ concentration ([Ca2+](i)) was increased byPACAP, but not VIP, in a concentration range from 10(-12) to 10(-8) M via the PAC(1)-R in isolated single cells from the rat neural fold. This activation of the cells by PACAP was mimicked by agonists and inhibited by antagonists of the cAMP/PKA and PLC/PKC cascades. These data indicate that PACAP/PAC(1)-R is linked to [Ca2+](i) signaling via two G-protein-coupled proteinkinase pathways and may thereby play an important role in early neurodevelopment. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:44:52