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Titolo:
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin
Autore:
Kuroda, N; Mizushima, S; Guo, LM; Jin, YL; Tao, LH; Miyazaki, E; Toi, M; Naruse, K; Hiroi, M; Enzan, H;
Indirizzi:
Kochi Med Sch, Dept Pathol 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 thol 1, Nanko Ku, Kochi 7838505, Japan Chikamori Hosp, Dept Surg, Kochi, Japan Chikamori Hosp Kochi JapanChikamori Hosp, Dept Surg, Kochi, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 4, volume: 51, anno: 2001,
pagine: 283 - 287
SICI:
1320-5463(200104)51:4<283:GCCOTA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-CATENIN; VERMIFORM APPENDIX; COLORECTAL-CANCER; GAMMA-CATENIN; TUMORS;
Keywords:
appendix; beta-catenin; E-cadherin; goblet cell carcinoid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kuroda, N Kochi Med Sch, Dept Pathol 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 nko Ku, Kochi 7838505, Japan
Citazione:
N. Kuroda et al., "Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin", PATHOL INT, 51(4), 2001, pp. 283-287

Abstract

Goblet cell carcinoids are rare neoplasms that predominantly occur in the appendix. In this report we present a case of goblet cell carcinoid of the appendix. A 58-year-old male patient complaining of pain in the right lowerquadrant was diagnosed with acute appendicitis and underwent an appendectomy. Histological examination of the resected appendix revealed goblet cell carcinoid. Infiltration of tumor cells beyond the appendix was observed andthe surgically resected margin was positive for tumor cells. Carcinoembryonic antigen (CEA) was diffusely detected by immunohistochemistry, and cytokeratin 20, neuron-specific enolase (NSE), chromogranin A and serotonin werefocally observed in the tumor cells. The expression of beta -catenin and E-cadherin was investigated to compare with that of typical rectal carcinoids (n = 3) and colon adenocarcinomas (n = 3). In normal colonic and rectal mucosae, beta -catenin and E-cadherin stained positive on the plasma membrane. In the case reported here, beta -catenin showed a preserved expression on the plasma membrane of goblet cell carcinoid; a pattern similar to typical carcinoids rather than to adenocarcinomas, However, E-cadherin demonstrated a reduced expression on the plasma membrane of the tumor cells. This staining pattern was identical to those both of carcinoids and of adenocarcinomas, These findings suggest the possibility that, in some cases, the adherens junctions of goblet cell carcinoids are similar to those of typical carcinoids rather than to those of adenocarcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:20:51