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Titolo:
Malignant phyllodes tumor of the breast with expression of osteonectin andvinculin
Autore:
Kuroda, N; Sugimoto, T; Ueda, S; Takahashi, T; Moriki, T; Sonobe, H; Miyazaki, E; Hayashi, Y; Toi, M; Hiroi, M; Enzan, H;
Indirizzi:
Kochi Med Sch, Dept Pathol 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 thol 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch, Dept Pathol 2, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 thol 2, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch, Dept Surg 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 Surg 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch, Cent Lab Dept, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 b Dept, Nanko Ku, Kochi 7838505, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 4, volume: 51, anno: 2001,
pagine: 277 - 282
SICI:
1320-5463(200104)51:4<277:MPTOTB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTOSARCOMA-PHYLLODES; DIFFERENTIATION; OSTEOPONTIN; MARKER; PROTEINS; CANCER;
Keywords:
malignant phyllodes tumor; osteonectin; vinculin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kuroda, N Kochi Med Sch, Dept Pathol 1, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 nko Ku, Kochi 7838505, Japan
Citazione:
N. Kuroda et al., "Malignant phyllodes tumor of the breast with expression of osteonectin andvinculin", PATHOL INT, 51(4), 2001, pp. 277-282

Abstract

Phyllodes tumor is a very rare neoplasm which accounts for 2.5% of all fibroepithelial lesions of the breast. The mesenchymal component of a malignant phyllodes tumor frequently contains heterologous components. We report a case of malignant phyllodes tumor. The patient was a 40-year-old woman witha lump on the left breast. Histological examination revealed the lump to be a malignant phyllodes tumor with foci of liposarcomatous differentiation. The mesenchymal tumor cells, including those in the liposarcomatous components, were found to express vimentin, osteonectin and vinculin, However, they showed no Immunoreaction to CAM 5.2, desmin, alpha -smooth muscle actin (ASMA), neuron-specific enolase (NSE) nor S-100, Ultrastructurally, the mesenchymal tumor cells were found to have abundant cytoplasmic organelles, but there was no evidence showing their differentiation to myofibroblasts, Further studies will be necessary to elucidate the significance of vinculin and osteonectin expression in malignant phyllodes tumor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 03:24:09