Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Diet acids and alkalis influence calcium retention in bone
Autore:
Buclin, T; Cosma, M; Appenzeller, M; Jacquet, AF; Decosterd, LA; Biollaz, J; Burckhardt, P;
Indirizzi:
CHUV, Univ Hosp, Div Clin Pharmacol, Lausanne, Switzerland CHUV LausanneSwitzerland sp, Div Clin Pharmacol, Lausanne, Switzerland CHUV, Univ Hosp, Dept Med, Lausanne, Switzerland CHUV Lausanne Switzerland V, Univ Hosp, Dept Med, Lausanne, Switzerland
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 6, volume: 12, anno: 2001,
pagine: 493 - 499
SICI:
0937-941X(2001)12:6<493:DAAAIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CALCIUM; POTASSIUM BICARBONATE; RAT OSTEOCLASTS; PROTEIN; EXCRETION; WOMEN; HYPERCALCIURIA; OSTEOPOROSIS; METABOLISM; INVITRO;
Keywords:
acid-forming nutrients; bone mineral content; calcium; calciuria; C-telopeptide; healthy subjects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Buclin, T Hop Beaumont 633, Div Clin Pharmacol, CH-1011 Lausanne, Switzerland Hop Beaumont 633 Lausanne Switzerland CH-1011 nne, Switzerland
Citazione:
T. Buclin et al., "Diet acids and alkalis influence calcium retention in bone", OSTEOPOR IN, 12(6), 2001, pp. 493-499

Abstract

The urine-acidifying properties of food constituents depend on their content of non-oxidizable acids or precursors. Acidifying constituents such as animal proteins may negatively affect calcium metabolism and accelerate boneresorption, thus representing an aggravating factor for osteoporosis. Thisfour-period, double-crossover study investigated whether a diet intervention specifically focused on acid load could modify calcium metabolism in humans. Eight healthy volunteers underwent a four-day metabolic preparation with two types of diets, one rich in acid ash-forming nutrients, and one providing base-forming nutrients (including bicarbonate-rich mineral water), both having similar contents of calcium, phosphate, sodium, proteins and calories. On the fourth day, a single oral dose of 1 g calcium was given, either as carbonate or as gluconolactate. Serial blood and urine samples revealed that the diet affected blood pH (average difference 0.014, p=0.002) and urine pH (average difference 1.02, p<0.0001) in the expected direction, but had no influence on the absorption of the calcium supplement. The acid-forming diet increased urinary calcium excretion by 74% when compared with the base-forming diet (p<0.0001), both at baseline and after the oral calcium load, and C-telopeptide excretion by 19% (p=0.01), suggesting a skeletal origin for the excess calcium output. This observation confirms that renally excreted acids derived from food influence calcium metabolism, and that alkalizing nutrients inhibit bone resorption. Further studies are needed to determine the clinical impact of dietary counseling for avoiding diet acids asa preventive measure against osteoporosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:42:49