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Titolo:
How the immune and nervous systems interact during disease-associated anorexia
Autore:
Konsman, JP; Dantzer, R;
Indirizzi:
Francois Magendie Inst, INSERM, U394, Bordeaux, France Francois Magendie Inst Bordeaux France , INSERM, U394, Bordeaux, France
Titolo Testata:
NUTRITION
fascicolo: 7-8, volume: 17, anno: 2001,
pagine: 664 - 668
SICI:
0899-9007(200107/08)17:7-8<664:HTIANS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-MOTIVATED BEHAVIOR; RECEPTOR MESSENGER-RNA; RAT-BRAIN; INTERLEUKIN-1 RECEPTOR; HOST-DEFENSE; FEEDING-BEHAVIOR; ARCUATE NUCLEUS; INFECTED-CELLS; SOLITARY TRACT; MOUSE-BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Konsman, JP Linkoping Univ, Dept Biomed & Surg, Div Cell Biol, S-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58185 85 Linkoping, Sweden
Citazione:
J.P. Konsman e R. Dantzer, "How the immune and nervous systems interact during disease-associated anorexia", NUTRITION, 17(7-8), 2001, pp. 664-668

Abstract

Anorexia is one of the most common symptoms associated with illness and constitutes an adaptive strategy in fighting acute infectious diseases. However, prolonged reduction in food intake and an increase in metabolic rate, as seen in the anorexia-cachexia syndrome, lead to depletion of body fat andprotein reserves, thus worsening the organism's condition. Because the central nervous system controls many aspects of food intake, soluble factors known as cytokines that are secreted by immune cells might act on the brain to induce anorexia during disease. This review focuses on the communicationpathways from the immune system to the brain that might mediate anorexia during disease. The vagus nerve is a rapid route of communication from the immune system to the brain, as subdiaphragmatic vagotomy attenuates the decrease in food-motivated behavior and c-Fos expression in the central nervoussystem in response to peripheral administration of the proinflammatory cytokine, interleukin-1 beta, or bacterial Lipopolysaccharide. At later time points after peripheral lipopolysaccharide administration, interleukin-1 itself acts in the brain to mediate anorexia and is found in the arcuate nucleus of the hypothalamus. The mechanisms by which interleukin-1 beta gains access to the brain and the potential role of neuropeptide-Y-containing neurons in the arcuate hypothalamus in mediating anorexia during disease are discussed. (C) Elsevier Science Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:03:09