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Titolo:
Influence of apolipoprotein-E phenotypes on postprandial lipoprotein metabolism after three different fat loads
Autore:
Fernandez-Miranda, C; Cancelas, P; Sanz, M; Porres, A; Gerique, JG;
Indirizzi:
Univ Hosp 12 Octubre, Unidad Lipidos, Serv Med Interna, Madrid 28041, Spain Univ Hosp 12 Octubre Madrid Spain 28041 Med Interna, Madrid 28041, Spain Fdn Jimenez Diaz, Lipids Lab, Madrid, Spain Fdn Jimenez Diaz Madrid Spain n Jimenez Diaz, Lipids Lab, Madrid, Spain
Titolo Testata:
NUTRITION
fascicolo: 7-8, volume: 17, anno: 2001,
pagine: 529 - 533
SICI:
0899-9007(200107/08)17:7-8<529:IOAPOP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; TRIGLYCERIDE-RICH LIPOPROTEINS; APO-E PHENOTYPE; E POLYMORPHISM; MYOCARDIAL-INFARCTION; RETINYL PALMITATE; ARTERY DISEASE; PLASMA; MEN; CHYLOMICRON;
Keywords:
postprandial lipemia; apolipoprotein-E polymorphism; retinyl palmitate; triacylglycerols; chylomicrons; fat-loading test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez-Miranda, C Univ Hosp 12 Octubre, Unidad Lipidos, Serv Med Interna, Madrid 28041, Spain Univ Hosp 12 Octubre Madrid Spain 28041 8041, Spain
Citazione:
C. Fernandez-Miranda et al., "Influence of apolipoprotein-E phenotypes on postprandial lipoprotein metabolism after three different fat loads", NUTRITION, 17(7-8), 2001, pp. 529-533

Abstract

aim of this study was to evaluate the postprandial response to three fat-loading tests in healthy subjects with different apolipoprotein E (apoE) phenotypes. Thirty-four subjects were studied: 15 with apoE3/3 (7 men and 8 women), 12 with apoE4/3 (5 men and 7 women), and 7 with apoE2/3 (4 men and 3 women). All received three oral fat loads at 1-wk intervals in meals rich in monounsaturated fatty acid, polyunsaturated fatty acid, and saturated fatty acid, with retinyl palmitate (60000 IU/m(2) of aqueous vitamin A) to quantify lipoproteins secreted by the intestine. No significant differences inpostprandial lipoproteins were found between the three different fat loads. Peaks and incremental areas under the curve of retinyl palmitate in non-chylomicron fractions were higher in the apoE2/3- than in the apoE3/3- and apoE4/3-phenotype groups in meals rich in monounsaturated and polyunsaturated fatty acids (P < 0.5). When the three fat loads were analyzed together, the incremental area under the curve of retinyl palmitate was much higher inthe apoE2/3- than in the other apoE-phenotype groups (P = 0.0004). In conclusion, the magnitude of intestinal lipoproteins after fat load, especiallywith monosaturated and polyunsaturated fatty acids, is higher in subjects with apoE2/3 than in those with apoE3/3 and apoE4/3 phenotype. (C) ElsevierScience Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 20:15:57