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Titolo:
Tc-99(m)-tetrofosmin scintimammography for detecting breast cancer: a comparative study with Tc-99(m)-MIBI
Autore:
Horne, T; Pappo, I; Cohen-Pour, M; Baumer, M; Orda, R;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Assaf Harofeh Med Ctr, Inst Nucl Med, IL-70300 Zerifin, Israel Tel Aviv Univ Zerifin Israel IL-70300 Nucl Med, IL-70300 Zerifin, Israel
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 7, volume: 22, anno: 2001,
pagine: 807 - 811
SICI:
0143-3636(200107)22:7<807:TSFDBC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TC-99M TETROFOSMIN; TECHNETIUM-99M-MIBI SCINTIGRAPHY; NEOADJUVANT CHEMOTHERAPY; DENSE BREAST; CARCINOMA; MAMMOGRAPHY; MORTALITY; DIAGNOSIS; LESIONS; TRENDS;
Keywords:
Tc-99(m)-sestamibi; scintimammography; breast cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pappo, I Tel Aviv Univ, Sackler Fac Med, Assaf Harofeh Med Ctr, Dept Surg A, IL-70300 Zerifin, Israel Tel Aviv Univ Zerifin Israel IL-70300 IL-70300 Zerifin, Israel
Citazione:
T. Horne et al., "Tc-99(m)-tetrofosmin scintimammography for detecting breast cancer: a comparative study with Tc-99(m)-MIBI", NUCL MED C, 22(7), 2001, pp. 807-811

Abstract

Scintimammography using Tc-99(m)-MIBI (Tc-99(m)-sestamibi) has demonstrated promising results in the detection of breast cancer. Recently scintimammography using Tc-99(m)-tetrofosmin has been suggested as a better diagnostictool and a more convenient agent to use in this condition. In this study we compared both agents in 35 consecutive women with abnormal mammographic or physical findings. Thirty-four of them underwent MIBI scan, followed by tetrofosmin scan 2 days later (performed on all 35 women). Within 2 weeks, apathological diagnosis was obtained either by needle or open biopsy. In both scans the uptake ratio between the lesion and the background uptake was calculated. Twenty patients who underwent tetrofosmin scan and 19 patients with MIBI scan had malignant breast rumours, while 15 women had benign lesions. The sensitivity, specificity, positive and negative predictive values and total accuracy of the MIBI scan were 89.4%, 80%, 85%, 85.7% and 85.3%, respectively; almost identical values were obtained with tetrofosmin (90%, 80%, 85.6%, 85.7% and 85.7%, respectively). The uptake ratios in the MIBI and tetrofosmin scans were 1.68 +/- 0.52 and 1.7 +/- 0.47, respectively. No differences were found between the two scintimammographies in all the parameters examined. In conclusion, MIBI and tetrofosmin breast scans are accurate and equally efficient for the detection of breast malignancies. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:25:08