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Titolo:
Differentiating between progressive supranuclear palsy and corticobasal degeneration by brain perfusion SPET
Autore:
Zhang, L; Murata, Y; Ishida, R; Saitoh, Y; Mizusawa, H; Shibuya, H;
Indirizzi:
Tokyo Med & Dent Univ, Fac Med, Dept Radiol, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 7, volume: 22, anno: 2001,
pagine: 767 - 772
SICI:
0143-3636(200107)22:7<767:DBPSPA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; HYPOMETABOLISM; PATTERN;
Keywords:
Tc-99m-ethyl cysteinate dimer; single-photon emission computed tomography; progressive supranuclear palsy; corticobasal degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, L Tokyo Med & Dent Univ, Fac Med, Dept Radiol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 , Japan
Citazione:
L. Zhang et al., "Differentiating between progressive supranuclear palsy and corticobasal degeneration by brain perfusion SPET", NUCL MED C, 22(7), 2001, pp. 767-772

Abstract

The purpose of this study was to evaluate the usefulness of brain perfusion single photon emission computed tomography (SPET) to differentiate between progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Twelve patients with PSP and 12 with CBD were examined by brain perfusion SPET using Tc-99(m)-ethyl cysteinate dimer (Tc-99(m)-ECD). The regions of interest (ROIs) were five cortical regions, the basal ganglia, the thalamus,the cerebellar cortex and the brain stem. The mean regional cerebral bloodflow (CBF) and the mean right/left asymmetry index in each ROI were calculated. The asymmetry index of the regional CBF was significantly higher in CBD patients compared with PSP patients in ail of the cortical regions and in the basal ganglia. The greatest differences in asymmetry were in the parietal cortex (P<0.001), high frontal cortex (P<0.001), frontal cortex (P<0.005), temporal cortex (P<0.01) and basal ganglia (P<0.01). Significant asymmetry was also detected in the occipital cortex (P<0.05). No significant difference in asymmetry was found in the thalamus or the cerebellum. There were no significant differences between the two groups in any of the regional CBF values. In conclusion, brain perfusion SPET with Tc-99(m)-ECD is usefulin detecting the significantly higher perfusion asymmetry in CBD patients compared with PSP patients in all cortical regions and in the basal ganglia. SPET may be a useful tool for differentiating between PSP and CBD. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:28:39