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Titolo:
SIGNIFICANCE OF THE THROMBOLYSIS IN MYOCARDIAL-INFARCTION SCORING SYSTEM IN ASSESSING INFARCT-RELATED ARTERY REPERFUSION AND MORTALITY-RATES AFTER ACUTE MYOCARDIAL-INFARCTION
Autore:
FATHORDOUBADI F; HUEHNS TY; ALMOHAMMAD A; BEATT KJ;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,CTR CLIN SCI,DU CANE RD LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH LONDON ENGLAND HAMMERSMITH HOSP,DEPT CARDIOL LONDON ENGLAND
Titolo Testata:
The American heart journal
fascicolo: 1, volume: 134, anno: 1997,
pagine: 62 - 68
SICI:
0002-8703(1997)134:1<62:SOTTIM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE PLASMINOGEN-ACTIVATOR; LEFT-VENTRICULAR FUNCTION; RANDOMIZED TRIAL; ELECTROCARDIOGRAPHIC EVIDENCE; INTRACORONARY STREPTOKINASE; CORONARY REOCCLUSION; ADJUNCTIVE THERAPY; PERFUSION STATUS; RT-PA; PATENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
F. Fathordoubadi et al., "SIGNIFICANCE OF THE THROMBOLYSIS IN MYOCARDIAL-INFARCTION SCORING SYSTEM IN ASSESSING INFARCT-RELATED ARTERY REPERFUSION AND MORTALITY-RATES AFTER ACUTE MYOCARDIAL-INFARCTION", The American heart journal, 134(1), 1997, pp. 62-68

Abstract

Thrombolysis in Myocardial Infarction (TIMI) flow scores were originally devised as semiquantitative ongiographic measures of coronary artery perfusion. Several studies have indicated an important relation between different TIMI flow grades at 90 minutes after thrombolysis and clinical outcome. To further evaluate this relation we conducted a metaonalysis of all angiographic, postinfarction trials that studied the relation between individual 90-minute TIMI flow grades and mortality rates. In 4687 pooled patients, the mortality rate was lowest in patients with TIMI grade 3 flow (3.7%) and significantly lower than those with TIMI 2 (6.6%, p = 0.0003; odds ratio 0.55; 95% confidence interval [CI] 0.4% to 0.76%) or TIMI 0/1 flow (9.2%, p < 0.0001; odds ratio 0.38; 95% CI 0.29% to 0.5%), The mortality rate difference between TIMI grade 2 and TIMI grade 0/1 patients was also significant (p = 0.02; oddsratio 0.7; 95% CI 0.51% to 0.94%). This study confirms the importanceof achieving rapid and complete reperfusion after acute myocardial infarction with the best outcome associated with 90-minute TIMI 3 flow. Furthermore, it shows that although TIMI 2 flow (partial perfusion) isnot equivalent to TIMI 3 flow, it nevertheless still confers a significant survival benefit compared with TIMI Flow 0/1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:35:49