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Titolo:
Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats
Autore:
Okamoto, S; Kimura, K; Saito, M;
Indirizzi:
Hokkaido Univ, Grad Sch Vet Med, Dept Biomed Sci, Biochem Lab, Sapporo, Hokkaido 0600818, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600818 oro, Hokkaido 0600818, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 307, anno: 2001,
pagine: 179 - 182
SICI:
0304-3940(20010720)307:3<179:AEOLIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; NERVOUS-SYSTEM; BRAIN; LOCALIZATION; CRF; NEUROPEPTIDE; EXPRESSION; TISSUES;
Keywords:
leptin; corticotropin-releasing hormone; urocortin; food intake; hypothalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Saito, M Hokkaido Univ, Grad Sch Vet Med, Dept Biomed Sci, Biochem Lab, Sapporo, Hokkaido 0600818, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600818 aido 0600818, Japan
Citazione:
S. Okamoto et al., "Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats", NEUROSCI L, 307(3), 2001, pp. 179-182

Abstract

Leptin is a key afferent signal that decreases food intake and increases energy expenditure by acting on the specific receptors in the hypothalamus. Corticotropin-releasing hormone (CRH) and its homologous peptide, urocortin, are also known to have a potent anorectic effect when given intracranially. To determine possible involvement of these two peptides in the leptin-induced anorexia, in the present study, food intake was measured in rats pretreated with antibodies against CRH and urocortin. In the control rats without antibody pretreatment, intracerebroventricular (icv) injection of leptin(0.1-1 mug/rat) suppressed nocturnal food intake. The anorectic effect of leptin was substantially attenuated in rats pretreated with icy injection of an anti-CRH antibody, but not with an anti-urocortin antibody. These results suggest that the anorectic effect of leptin is mediated by CRH, but notby urocortin, in the hypothalamus. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:31:59