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Titolo:
Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic
Autore:
Blanchard, DC; Griebel, G; Blanchard, RJ;
Indirizzi:
Univ Hawaii, Pacific Biomed Res Ctr, Honolulu, HI 96822 USA Univ Hawaii Honolulu HI USA 96822 Biomed Res Ctr, Honolulu, HI 96822 USA John A Burns Sch Med, Dept Genet & Mol Biol, Honolulu, HI 96822 USA John ABurns Sch Med Honolulu HI USA 96822 l Biol, Honolulu, HI 96822 USA Sanofi Synthelabo, CNS, Res Dept, Bagneux, France Sanofi Synthelabo Bagneux France helabo, CNS, Res Dept, Bagneux, France Univ Hawaii, Dept Psychol, Honolulu, HI 96822 USA Univ Hawaii Honolulu HIUSA 96822 i, Dept Psychol, Honolulu, HI 96822 USA
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 3, volume: 25, anno: 2001,
pagine: 205 - 218
SICI:
0149-7634(200105)25:3<205:MDBPAB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED T-MAZE; SEROTONIN REUPTAKE INHIBITORS; RECEPTOR AGONIST FLESINOXAN; PLACEBO-CONTROLLED TRIAL; GRAY-INDUCED AVERSION; MONOAMINE-OXIDASE-A; SWISS-WEBSTER MICE; EXPERIMENTAL-MODEL; CONFLICT BEHAVIOR; TEST BATTERY;
Keywords:
defense; defensive behavior; flight; panic; mouse models; panicolytics; panicogenic; behavioral assays;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Blanchard, DC Univ Hawaii, Pacific Biomed Res Ctr, Honolulu, HI 96822 USA Univ Hawaii Honolulu HI USA 96822 r, Honolulu, HI 96822 USA
Citazione:
D.C. Blanchard et al., "Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic", NEUROSCI B, 25(3), 2001, pp. 205-218

Abstract

The natural defensive behaviors of laboratory mice have been evaluated in both seminatural and highly structured situations; and characterized in terms of eliciting stimuli, response to pharmacological agents, behavior patterns, and outcome or effect on the social and physical environment. The defense patterns of laboratory mice and rats are generally similar, but mice show risk assessment on initial exposure to highly threatening stimuli while rats do not, while rats display alarm vocalizations, missing in mice. Quantitative differences in freezing and flight fur laboratory mice and rats appear to largely reflect domestication effects, with wild mice and rats more similar to each other. This nexus of detailed within-species and comparative data on defense patterns makes it possible to reliably elicit specific defenses in mice or rats in an experimental context, providing well-validatedassays of the natural defensive behaviors themselves, as opposed to 'models' of defense. The mouse-rat. comparisons indicate considerable cross-species generality for these defense patterns, as does a scattered but considerable literatureon other mammalian species, generally involving field studies and typically focusing on those aspects of defensive behavior that are visible at a distance, such as vigilance, or flight. Although potential homologies between normal mouse and human defense systems should ideally involve all four pattern components (stimulus, organismic factors, response characteristics, outcome), predictive validity in terms of response to drugs active against specific defensive psychopathology is the most extensively investigated of these. Flight, as measured in the Mouse Defense Test Battery shows a consistently appropriate response to panicolytic, panicogenic, and panic-neutral drugs, while some other predictive 'panic models' (dPAG-stimulation; DMH-inhibition; possibly conditioned suppression of drinking paradigms) also elicit and (indirectly) measure behaviors potentially related to flight. Models unrelated to flight (e.g. ultrasonic vocalization to conditioned stimuli); orfor which flight elements may a relatively minor contributor to the behavior measured Elevated T-maze) are less predictive of panicolytic or panicogenic action. These findings indicate that natural defensive behaviors provide a well-characterized pattern for analysis of effects of genetic or other physiological manipulations in the mouse, and may also serve as a model foranalysis of defense-related human psychopathology. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:02:03