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Titolo:
Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain
Autore:
Tanaka, K; Nogawa, S; Ito, D; Suzuki, S; Dembo, T; Kosakai, A; Fukuuchi, Y;
Indirizzi:
Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Neurol, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2169 - 2174
SICI:
0959-4965(20010720)12:10<2169:AONOPC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; CHONDROITIN-SULFATE PROTEOGLYCAN; PRECURSOR CELLS; ADULT; PHOSPHORYLATION;
Keywords:
cerebral infarction; chondroitin sulfate; myelination; oligodendrocyte; reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, K Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 yo 1608582, Japan
Citazione:
K. Tanaka et al., "Activation of NG2-positive oligodendrocyte progenitor cells during post-ischemic reperfusion in the rat brain", NEUROREPORT, 12(10), 2001, pp. 2169-2174

Abstract

This study examines the alteration of oligodendrocyte progenitor cells which express membrane NG2 chondroitin sulfate proteoglycan after focal ischemia in the rat brain. Adult male Sprague-Dawley rats were subjected to 90 min occlusion of the middle cerebral artery, followed by reperfusion time of up to 2 weeks. The distribution and morphological changes in NG2-positive oligodendrocyte progenitor cells were immunohistochemically examined. Stellate-shaped NG2-positive cells with multiple branched processes were detectedin both the gray and white matter of normal brain. After 2 weeks of reperfusion, NG2-positive cells in the area surrounding the infarction site (peri-infarct area) clearly showed enlarged cell bodies with hypertrophied processes. These stained strongly for NG2. Although the number of NG2-positive cells was increased significantly in the peri-infarct area. it decreased markedly in the infarct core compared to controls. Double immunostaining revealed that these NG2-positive cells were neither astrocytes nor microglia, but NG2-positive oligodendrocyte progenitor cells. These progenitor cells areknown to differentiate into oligodendrocytes. As such, this upregulation of NG2 expression may be an adaptive mechanism attempting to remyelinate ratbrain tissue after ischemic insult. Only further study will elucidate thishypothesis. NeuroReport 12:2169-2174 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:22:44