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Titolo:
Transfer of the apoptotic message in sister cultures of cerebellar neurons
Autore:
De Berardinis, MA; Ciotti, MT; Amadoro, G; Galli, C; Calissano, P;
Indirizzi:
CNR, Ist Neurobiol & Med Mol, I-00137 Rome, Italy CNR Rome Italy I-00137CNR, Ist Neurobiol & Med Mol, I-00137 Rome, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2137 - 2140
SICI:
0959-4965(20010720)12:10<2137:TOTAMI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID-BETA-PEPTIDE; GRANULE NEURONS; NEUROTOXICITY; CELLS; INDUCTION; CALCIUM; DISEASE;
Keywords:
apoptosis; beta A; cerebellar granule cells; paracrine loop;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Calissano, P CNR, Ist Neurobiol & Med Mol, Viale C Marx 15, I-00137 Rome, Italy CNR Viale C Marx 15 Rome Italy I-00137 , I-00137 Rome, Italy
Citazione:
M.A. De Berardinis et al., "Transfer of the apoptotic message in sister cultures of cerebellar neurons", NEUROREPORT, 12(10), 2001, pp. 2137-2140

Abstract

In vitro cultured cerebellar granule cells (cgc) undergo apoptotic death when the depolarising concentration of KCl 25 mM is adjusted to 5 mM. We investigated whether the apoptotic message can be transferred from a group of neurons to neighbouring but separated sister cultures by resorting to two different culture systems, one based on the use of concentric dishes, the other employing the transwells. The extent of transferred death was 38.6% in the two dishes system and 31.3% in the transwell system. The transfer of such death-inducing signal(s), accompanied by chromatin condensation, was inhibited by actinomicin D. preliminary experiments aimed at identifying such apoptosis-inducing signal(s) suggest the involvement of beta -amyloid fragment(s). NeuroReport 12:2137-2140 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:42:17