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Titolo:
Miniature postsynaptic currents depend on Ca2+ released from internal stores via PLC/IP3 pathway
Autore:
Han, MH; Kawasaki, A; Wei, JY; Barnstable, CJ;
Indirizzi:
Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ol & Visual Sci, New Haven, CT 06520 USA
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2203 - 2207
SICI:
0959-4965(20010720)12:10<2203:MPCDOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; TRANSMITTER RELEASE; NEURONAL-SYNAPTOBREVIN; HIPPOCAMPAL-NEURONS; ACINAR-CELLS; CALCIUM; RAT; NEUROTRANSMITTER; DROSOPHILA; MUTATIONS;
Keywords:
Ca2+; internal stores; IP3; miniature; neurotransmitter release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Barnstable, CJ Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, POB 208061,333 Cedar St,New Haven, CT 06520 USA Yale Univ POB 208061,333 Cedar St New Haven CT USA 06520 SA
Citazione:
M.H. Han et al., "Miniature postsynaptic currents depend on Ca2+ released from internal stores via PLC/IP3 pathway", NEUROREPORT, 12(10), 2001, pp. 2203-2207

Abstract

Miniature postsynaptic currents (mPSCs) were examined on autaptic innervation of single rat retinal ganglion cells in low density cultures. Removal of Ca2+ from bath solution or blocking of Ca2+ channels by Cd2+ had no detectable effect on mPSC frequency or amplitude. Thapsigargin, an agent for mobilization of Ca2+ from internal stores, increased mPSC frequency 3-5-fold in control, Ca2+-free or Cd2+-containing solutions. The inositol 1,4,5-triphosphate (IP3) receptor antagonist, heparin; the phospholipase C (PLC) inhibitor, U73 122; and caffeine abolished mPSC or decreased mPSCs frequency. Calcium imaging showed that cytosolic Ca2+ was increased by thapsigargin and decreased by caffeine. These data demonstrate that internal store-released Ca2+ regulated by the PLC/IP3/IP3-receptor pathway has critical contribution to generation and control of miniature release in retinal ganglion cells. NeuroReport 12:2203-2207 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:16:43