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Titolo:
Systemic morphine reduces the wind-up of trigeminal nociceptive neurons
Autore:
Duale, C; Raboissen, P; Molat, JL; Dallel, R;
Indirizzi:
Fac Chirurg Dent, Lab Physiol Orafaciale, F-63000 Clermont Ferrand, FranceFac Chirurg Dent Clermont Ferrand France F-63000 lermont Ferrand, France AstraZeneca R&D Sodertalje, Local Discovery Res Area CNS & Pain Control, S-14157 Huddinge, Sweden AstraZeneca R&D Sodertalje Huddinge Sweden S-14157 4157 Huddinge, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2091 - 2096
SICI:
0959-4965(20010720)12:10<2091:SMRTWO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; C-FIBER REFLEX; NUCLEUS ORALIS; DORSAL HORN; INHIBITORY CONTROLS; SUPERFICIAL LAYERS; CONVERGENT NEURONS; OPIOID RECEPTOR; MU-OPIOIDS; PAIN;
Keywords:
antinociception; central sensitization; electrophysiology; opiates; pain; temporal summation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dallel, R Fac Chirurg Dent, Lab Physiol Orafaciale, 11 Bd Charles de Gaulle, F-63000Clermont Ferrand, France Fac Chirurg Dent 11 Bd Charles de GaulleClermont Ferrand France F-63000
Citazione:
C. Duale et al., "Systemic morphine reduces the wind-up of trigeminal nociceptive neurons", NEUROREPORT, 12(10), 2001, pp. 2091-2096

Abstract

We assessed the effects of intravenous morphine on the windup of nociceptive neurons of the spinal trigeminal nucleus oralis (Sp50). Extracellular recordings of Sp50 nociceptive convergent neurons were performed in intact halothane-anesthetized rats. Wind-up of C-fiber-evoked responses was elicitedby repetitive electrical stimulation (train of 16 shocks, 0.66 Hz) of their receptive field at C-fiber intensity (3 times the threshold). Wind-up wastested for its sensitivity to morphine (6 mg/kg,i.v.), and the specificityof the effects was verified with naloxone (0.4 mg/kg, i.v.). Nineteen convergent neurons displaying wind-up were recorded. Morphine reduced the windup of all but one. In five cases, notwithstanding a reduced wind-up, the neuronal response evoked by the first stimulus in the train (initial input) was unexpectedly increased. Naloxone always antagonized morphine inhibitory effects on the wind-up. When administered systemically, morphine reduced thewindup of trigeminal nociceptive neurons. This inhibitory effect occurred independently of morphine's ability to affect the initial C-fiber-evoked input. Our findings support the idea that systemic morphine probably blocks wind-up by acting at opioid receptors located postsynaptically to nociceptive primary afferents. NeuroReport 12:2091-2096 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:56:08