Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation
Autore:
Zhou, J; Fu, Y; Tang, XC;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R ChinaChinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2073 - 2077
SICI:
0959-4965(20010720)12:10<2073:HAPRPC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PC12 CELLS; CEREBRAL-ISCHEMIA; DEATH; APOPTOSIS; BCL-2; NEURONS; BAX; MECHANISM; NECROSIS; INJURY;
Keywords:
apoptosis; apoptosis-related genes; huperzine A; oxygen-glucose deprivation; PC12 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Tang, XC Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China Chinese Acad Sci 294 Tai Yuan Rd Shanghai Peoples R China 200031
Citazione:
J. Zhou et al., "Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation", NEUROREPORT, 12(10), 2001, pp. 2073-2077

Abstract

The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation. nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p53, bcl-2 and box mRNA after OGD indicated that these genes played important roles in apoptosis. Pre-incubation of the cells for 2 h with 1 muM HupA significantly attenuated apoptosis. The same treatment also reduced the up-regulation of c-jun and box as well as the down-regulation of bcl-2. These data suggest the ability of HupA to attenuate apoptosis induced by OGD may result from its capability to alter the expression of apoptosis-related genes. NeuroReport 12:2073-2077 (C) 2001 Lippincott Williams& Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:03:54