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Titolo:
Magnesium potentiation of the function of native and recombinant GABA(A) receptors
Autore:
Moykkynen, T; Uusi-Oukari, M; Heikkila, J; Lovinger, DM; Luddens, H; Korpi, ER;
Indirizzi:
Univ Turku, Dept Pharmacol & Clin Pharmacol, Turku, Finland Univ Turku Turku Finland ept Pharmacol & Clin Pharmacol, Turku, Finland Vanderbilt Univ, Sch Med, Dept Physiol & Mol Biophys, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 l Biophys, Nashville, TN 37212 USA Univ Mainz, Dept Psychiat, Clin Res Grp, D-6500 Mainz, Germany Univ MainzMainz Germany D-6500 iat, Clin Res Grp, D-6500 Mainz, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2175 - 2179
SICI:
0959-4965(20010720)12:10<2175:MPOTFO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUTYLBICYCLOPHOSPHOROTHIONATE BINDING; MODULATION; SUBTYPES; PHARMACOLOGY; EXPRESSION; INHIBITION; DIVERSITY; NEURONS; SLICES; ZN-2+;
Keywords:
divalent cations; electrophysiology; GABA(A) receptors; GABA(A) receptor subtypes; ion channels; ligand autoradiography; magnesium; TBPS; Xenopus oocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Korpi, ER Univ Turku, Dept Pharmacol & Clin Pharmacol, Turku, Finland UnivTurku Turku Finland col & Clin Pharmacol, Turku, Finland
Citazione:
T. Moykkynen et al., "Magnesium potentiation of the function of native and recombinant GABA(A) receptors", NEUROREPORT, 12(10), 2001, pp. 2175-2179

Abstract

Mg2+ decreased basal and GABA-inhibited t-butylbicyclo-sphosphoro[S-35]thionate binding to GABA(A) receptor ion channels in rat brain sections up to 1 mM, but increased the binding at 10 mM. The Mg2+-effect was detectable inthe presence of a specific GABA site competitive antagonist. Two-electrodevoltage clamp recordings of recombinant alpha1 beta2 gamma 2S, alpha1 beta2, alpha2 beta2 gamma 2S and alpha2 beta2 GABA(A) receptors revealed a potentiation by 0.1-1 mM Mg2+ of EC20 GABA-evoked ion currents. At 10 mM, Mg2+ decreased the currents. In the absence of GABA. Mg2+ did not evoke any currents. The results show that physiologically relevant Mg2+ concentrations affect the GABA responses on GABA(A) receptors in native and the main recombinant receptor subtypes, suggesting putative Mg2+ binding sites on the receptor complex. NeuroReport 12:2175-2179 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 20/01/20 alle ore 04:44:55